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[儿童癌症治疗患者的肾脏远期效应]

[Renal late effects in patients treated for cancer in childhood].

作者信息

Sudour-Bonnange Hélène, Vanrenterghem Audrey, Nobili François, Guigonis Vincent, Boudailliez Bernard

机构信息

Centre Oscar-Lambret, unité d'oncologie pédiatrique, 3, rue Frederic-Combemale, 59000 Lille, France.

CHU Nord Amiens, Département de Pédiatrie, 80000 Amiens, France.

出版信息

Bull Cancer. 2015 Jul-Aug;102(7-8):627-35. doi: 10.1016/j.bulcan.2015.03.016. Epub 2015 Apr 29.

Abstract

Impaired renal function may occur following multimodal treatment of cancer in childhood. Renal late effects caused by chemotherapy, renal surgery and/or radiotherapy are now well described; but little is known about their prevalence and time of development. Herein, we provide a synthesis of the different renal complications that may occur with their physiopathology in relation with specific treatment exposures. This review summarized the literature that supported the recommendations issued by the long-term follow-up group of the "Société française des cancers de l'enfant (SFCE)" for childhood cancer survivors at risk for nephrotoxicity (www.sfce.org ; www.soc-nephrologie.org/SNP/index.htm). We developed these monitoring elements and the lifestyle recommendations for all asymptomatic survivors.

摘要

儿童癌症多模式治疗后可能会出现肾功能受损。化疗、肾脏手术和/或放疗引起的肾脏晚期效应现已得到充分描述;但对其发生率和发展时间却知之甚少。在此,我们综合阐述了与特定治疗暴露相关的可能发生的不同肾脏并发症及其病理生理学。本综述总结了支持“法国儿童癌症协会(SFCE)”长期随访小组针对有肾毒性风险的儿童癌症幸存者发布的建议的文献(www.sfce.orgwww.soc-nephrologie.org/SNP/index.htm)。我们为所有无症状幸存者制定了这些监测要点和生活方式建议。

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