Mallick Supriya, Das Sudeep, Benson Rony, Roshan Vikas, Bhasker Suman
Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.
J Egypt Natl Canc Inst. 2015 Sep;27(3):113-7. doi: 10.1016/j.jnci.2015.04.003. Epub 2015 Apr 29.
To analyze the clinical outcome of primary orbital lymphoma (POL) patients treated with a combined modality approach with local radiotherapy after induction chemotherapy.
We retrospectively retrieved demographic, treatment and outcome data of patients treated for POL from 2000 to 2010. The charts were reviewed and the data were tabulated in a predesigned pro-forma.
23 patients of POL were found evaluable. Median age was 55 years (range 24-70 years). Of 23 patients, 15 were male and 8 female, making the male:female ratio approximately 1.9:1. Patients were thoroughly evaluated and staged. All but one patient received multi agent chemotherapy. Radiotherapy was delivered for all cases. Radiation was delivered by 3DCRT technique. Median dose of radiation was 45Gy (range 20-45Gy). Median follow up was 26.8 months. None of the patients had any evidence of local failure or systemic progression.
A combined modality therapy with a combination of CHOP/COP based chemotherapy and moderate dose of radiotherapy imparts excellent long term local and systemic disease control.
分析诱导化疗后联合局部放疗的综合治疗方法治疗原发性眼眶淋巴瘤（POL）患者的临床疗效。
我们回顾性检索了2000年至2010年接受POL治疗患者的人口统计学、治疗和结局数据。查阅病历并将数据填入预先设计的表格。
发现23例POL患者可评估。中位年龄为55岁（范围24 - 70岁）。23例患者中，15例为男性，8例为女性，男女比例约为1.9:1。对患者进行了全面评估和分期。除1例患者外，所有患者均接受了多药化疗。所有病例均进行了放疗。采用三维适形放疗（3DCRT）技术进行放疗。中位放疗剂量为45Gy（范围20 - 45Gy）。中位随访时间为26.8个月。所有患者均无局部失败或全身进展的证据。
基于CHOP/COP的化疗联合中等剂量放疗的综合治疗方法能实现出色的长期局部和全身疾病控制。
