Waldon Karen, Abbas Jonathan Raihan, Shakir Savana, Afify Samir
Pennine Acute NHS Hospitals Trust, Manchester, UK.
Salford Royal NHS Foundation Trust, Manchester, UK.
BMJ Case Rep. 2015 May 2;2015:bcr2014207135. doi: 10.1136/bcr-2014-207135.
Gastroenteropancreatic neuroendocrine tumours are associated with development of further primary tumours. Certain conditions give an inherited predisposition to developing neoplasia. To the best of our knowledge, this is the first paper to report a patient with neuroendocrine tumour and three other tumours: a further bowel cancer, a brain tumour and a skin cancer. We report a case of a 42-year-old Caucasian man presenting with clinical features of intestinal obstruction who on histopathology of surgical specimen was found to have two distinct tumours of the bowel: a colonic adenocarcinoma at the splenic flexure and a well-differentiated neuroendocrine tumour of the terminal ileum. His history included a basal cell carcinoma and a benign brain tumour. He had extensive family history of neoplasia suggesting an inherited predisposition. Our case demonstrates the importance of investigating patients with known neuroendocrine tumours for further malignancy and suggests that patients with multiple primary malignancies should be referred for genetic testing.
胃肠胰神经内分泌肿瘤与其他原发性肿瘤的发生有关。某些情况会使个体具有发生肿瘤的遗传易感性。据我们所知，本文是首例报告一名患有神经内分泌肿瘤及其他三种肿瘤的患者：另一例肠癌、一例脑肿瘤和一例皮肤癌。我们报告了一名42岁的白种男性患者，其表现出肠梗阻的临床特征，手术标本的组织病理学检查发现肠道有两种不同的肿瘤：脾曲处的结肠腺癌和回肠末端的高分化神经内分泌肿瘤。他的病史包括基底细胞癌和良性脑肿瘤。他有广泛的肿瘤家族史，提示存在遗传易感性。我们的病例证明了对已知神经内分泌肿瘤患者进行进一步恶性肿瘤筛查的重要性，并表明患有多种原发性恶性肿瘤的患者应转诊进行基因检测。
