Kapoor Garima, Salhan Sudha, Sarda Nivedita, Aggarwal Deepika
J Indian Med Assoc. 2014 Feb;112(2):96-9.
The aim of this study is to compare the effectiveness of 100 mg versus 200 mg mifepristone along with misoprostol for medical abortion in gestation upto 56 days. This is a prospective controlled study. Eighty women seeking medical abortion with a gestation up to 56 days were included in the study. The women were randomly allotted into two groups. They received 100 mg/200 mg mifepristone on day 1 followed by 800 mcg misoprostol two days later. Women who had not aborted completely by day 14, received a repeat dose of 400 mcg misoprostol and were evaluated on day 21 for completeness of the procedure. Five women in both the groups had incomplete abortion by day 14 (12.5%), while one woman in the test group had to undergo dilatation and evacuation on day 3 due to excessive bleeding. By repeating a second dose of misoprostol, all of them aborted completely and the complete abortion rates were markedly improved from 85% and 87.5% in the test and the control group, respectively to 97.5% and 100%, respectively. It may be concluded that 100 mg mifepristone is as effective as 200 mg and appears to be the lowest effective dose for medical abortion.
本研究旨在比较100毫克与200毫克米非司酮联合米索前列醇用于妊娠56天内药物流产的有效性。这是一项前瞻性对照研究。80名寻求妊娠56天内药物流产的女性被纳入研究。这些女性被随机分为两组。她们在第1天服用100毫克/200毫克米非司酮，两天后服用800微克米索前列醇。到第14天未完全流产的女性，接受400微克米索前列醇的重复剂量，并在第21天评估手术的完整性。两组均有5名女性在第14天流产不全（12.5%），而试验组有1名女性在第3天因出血过多不得不进行刮宫术。通过重复服用第二剂米索前列醇，她们均完全流产，完全流产率分别从试验组和对照组的85%和87.5%显著提高到97.5%和100%。可以得出结论，100毫克米非司酮与200毫克米非司酮效果相同，似乎是药物流产的最低有效剂量。
