Department of Gynecology and Obstetrics, The Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Int J Gynaecol Obstet. 2010 Nov;111(2):126-30. doi: 10.1016/j.ijgo.2010.06.008. Epub 2010 Aug 11.
To compare the efficacy of 1-day and 2-day mifepristone and misoprostol intervals for second trimester termination of pregnancy between 13 and 16 weeks.
A prospective randomized cohort study of 100 women who underwent voluntary termination between 13 and 16 weeks of gestation. Patients were randomly assigned to receive 200mg of oral mifepristone, followed 1 day (group 1) or 2 days (group 2) later by 600 μg of vaginal misoprostol. All patients received 400 μg of oral misoprostol every 6 hours for a maximum of 2 doses. Main outcome measure was successful abortion rate at 24 hours after the start of misoprostol treatment. Secondary outcome measures were induction-to-abortion interval and frequency of adverse events.
The 24-hour successful abortion rate was similar between groups 1 and 2 (47 [94%] vs 50 [100%]; P = 0.241). The mean misoprostol-to-abortion interval was also similar (7.0 ± 3.0 vs 6.8 ± 4.3 hours; P = 0.744). Among the 86 patients for whom histological examination of the products of conception was performed, retained chorionic villi rates were higher in the 1-day regimen group compared with the 2-day regimen group (46.2% [18/39] vs 29.8% [14/47]; P<0.001).
A 2-day mifepristone-misoprostol interval resulted in fewer incomplete abortions than a 1-day interval for second trimester termination of pregnancy between 13 and 16 weeks.
比较米非司酮和米索前列醇用于 13-16 周妊娠中期引产的 1 天和 2 天间隔的疗效。
这是一项前瞻性随机队列研究，共纳入 100 名在 13-16 孕周行自愿终止妊娠的患者。患者被随机分为两组，分别在口服米非司酮 200mg 后第 1 天（第 1 组）或第 2 天（第 2 组）给予 600μg 阴道米索前列醇。所有患者均接受 400μg 米索前列醇口服，每 6 小时 1 次，最多 2 次。主要结局测量指标是米索前列醇治疗开始后 24 小时的完全流产率。次要结局测量指标是引产至流产的间隔时间和不良反应的发生频率。
第 1 组和第 2 组的 24 小时完全流产率相似（47[94%]例 vs 50[100%]例；P=0.241）。米索前列醇至流产的间隔时间也相似（7.0±3.0 小时 vs 6.8±4.3 小时；P=0.744）。在 86 例行组织学检查的患者中，1 天方案组的残留绒毛组织率高于 2 天方案组（46.2%[18/39]例 vs 29.8%[14/47]例；P<0.001）。
与 1 天间隔相比，米非司酮-米索前列醇 2 天间隔用于 13-16 孕周妊娠中期引产可减少不完全流产的发生。
