[Changes in the mitochondrial oxidative enzyme activity in the skeletal muscles od rats during the recovery period after hypokinesia of varying duration].

Enzyme activity was measured in 164 white rats exposed to hypokinesia of varying duration. NAD- and NADP-dependent isocitrate dehydrogenases (ICDH) decreased on hypokinesia day 7 and returned to normal on recovery days 4-5. Their enzyme activity was diminished on hypokinesia day 15. NAD- and NADP-dependent ICDH returned to normal on recovery days 11 and 7, respectively. Activity of alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase (SDH) decreased immediately after hypokinesia and remained lowered till day 18. Activity of pyruvate dehydrogenase (PDH) was decreased on recovery days 1-3 and increased on days 9-17. After 30-day hypokinesia PDH activity was lower than normal on recovery days 2-14. 30-day hypokinesia led to reduction of ICDH, KGDH, and SDH. NADP-dependent ICDH returned to normal on recovery day 12 and other enzymes during the third week of readaptation. These results suggest that during recovery the enzymes that are responsible for energy metabolism restoration are first to return to normal.