Suzuki Hiromichi
Nihon Rinsho. 2015 Apr;73(4):629-33.
It is well known that there are differences in prevalence and progression of kidney disease between men and women. Several experimental models of chronic kidney disease (CKD) have revealed the different effects of gender on the course and responses to salt and vascular modulating substances. The prominent differences between men and women are attributable to sex hormones. Estrogen has profound effects on the renin-angiotensin system, producing alteration of renal function and structures. In this article, first, the differences in renal structure and function are introduced and then the effects of estrogen on renal hemodynamics and progression of renal diseases will be discussed.
众所周知，男性和女性在肾脏疾病的患病率和进展方面存在差异。几种慢性肾脏病（CKD）实验模型已经揭示了性别对病程以及对盐和血管调节物质反应的不同影响。男性和女性之间的显著差异归因于性激素。雌激素对肾素 - 血管紧张素系统有深远影响，会导致肾功能和结构的改变。在本文中，首先介绍肾脏结构和功能的差异，然后讨论雌激素对肾脏血流动力学和肾脏疾病进展的影响。
