Matsushita Hiroshi, Wakatsuki Akihiko
Nihon Rinsho. 2015 Apr;73(4):639-43.
Osteoporosis is more commonly found in women, thus making women more susceptible to fracture than men. The growth period is crucial to skeletal development, resulting in larger and stronger bones in males than in females. Estrogen deficiency after menopause is strongly associated with rapid resorption and loss of bone density, which contrasts with the gradual decline in sex steroids and bone mineral density seen in aging men. Although estrogen deficiency is more pronounced in women, it also plays a major role in the pathogenesis of osteoporosis in men.
骨质疏松症在女性中更为常见，因此女性比男性更容易发生骨折。生长发育期对骨骼发育至关重要，这使得男性的骨骼比女性更大更强壮。绝经后雌激素缺乏与骨密度的快速吸收和丧失密切相关，这与老年男性中甾体性激素和骨矿物质密度的逐渐下降形成对比。虽然雌激素缺乏在女性中更为明显，但它在男性骨质疏松症的发病机制中也起主要作用。
