Alroughani R, Akhtar S, Ahmed S F, Behbehani R, Al-Abkal J, Al-Hashel J
Division of Neurology, Amiri Hospital, Arabian Gulf Street, Sharq 13041, Kuwait; Neurology Clinic, Dasman Diabetes Institute, P.O. Box 1180, Dasman 15462, Kuwait.
Department of Community Medicine & Behavioural Sciences, Faculty of Medicine, University of Kuwait, PO Box 24923, Safat 13110, Kuwait.
J Neurol Sci. 2015;353(1-2):107-10. doi: 10.1016/j.jns.2015.04.025. Epub 2015 Apr 24.
This study aimed to assess the incidence and prevalence of pediatric-onset multiple sclerosis (POMS) along with temporal and gender differentials in these estimates in Kuwait.
We identified MS patients with pediatric (age <18 years) onset between 1994 and 2013 from national MS registry. Year and gender-specific incidence rate and prevalence estimates were computed. Multivariable Poisson regression analyses of time-series cross-sectional panel data were conducted to evaluate temporal and gender related variations in yearly POMS incidence rate and prevalence.
122 POMS patients were identified; of which 90 (73.8%) were females. During 2013, POMS incidence rate and prevalence (per 100,000) were 2.1 and 6.0 respectively. Multivariable Poisson regression model revealed statistically significant 5% increase in POMS incidence rate (p=0.002) and 6% increase in prevalence (p<0.001) from 1994 to 2013. Furthermore, during the study period, female children were more likely to have higher POMS incidence rate (relative rate=2.9; p<0.001) and prevalence (prevalence ratio=2.8; p<0.001).
The temporal increase and gender disparity in POMS incidence and prevalence corroborate the findings of earlier studies conducted elsewhere. Knowledge of increasing POMS burden may help in optimal planning for better management of patients in the region.
本研究旨在评估科威特儿童期多发性硬化症（POMS）的发病率和患病率，以及这些估计值在时间和性别上的差异。
我们从国家多发性硬化症登记处识别出1994年至2013年间发病的儿童（年龄<18岁）多发性硬化症患者。计算了按年份和性别划分的发病率和患病率估计值。对时间序列横断面面板数据进行多变量泊松回归分析，以评估每年POMS发病率和患病率在时间和性别方面的变化。
共识别出122例POMS患者；其中90例（73.8%）为女性。2013年，POMS发病率和患病率（每10万人）分别为2.1和6.0。多变量泊松回归模型显示，从1994年到2013年，POMS发病率有统计学意义的5%增长（p=0.002），患病率增长6%（p<0.001）。此外，在研究期间，女童更有可能有较高的POMS发病率（相对率=2.9；p<0.001）和患病率（患病率比=2.8；p<0.001）。
POMS发病率和患病率在时间上的增加以及性别差异证实了其他地方早期研究的结果。了解POMS负担的增加可能有助于该地区为更好地管理患者进行优化规划。
