CHU Clermont-Ferrand, Pédiatrie, Hôpital Estaing, 63003 Clermont-Ferrand, France; INSERM, CIC 1405, Unité CRECHE, 63001 Clermont-Ferrand, France; Clermont Université, Université Blaise Pascal, Laboratoire des Adaptations Métaboliques en conditions Physiologiques et Physiopathologiques (AME2P), EA 3533, 63001 Clermont-Ferrand, France.
Clermont Université, Université Blaise Pascal, Laboratoire des Adaptations Métaboliques en conditions Physiologiques et Physiopathologiques (AME2P), EA 3533, 63001 Clermont-Ferrand, France.
Autoimmun Rev. 2015 Aug;14(8):726-34. doi: 10.1016/j.autrev.2015.04.007. Epub 2015 Apr 29.
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease characterized by persistent joint inflammation that manifests as joint pain and swelling and limited range of joint motion. In healthy subjects, the literature reports that physical activity has an anti-inflammatory effect. In JIA patients, exercise could be used as a therapeutic tool to counteract disease-related inflammation and thereby improve clinical symptoms, although transient flare of pain could be the price to pay. Indeed, in patients with a chronic inflammatory disease, physical activity is prone to exacerbate underlying inflammatory stress. Physical activity improves quality of life and symptoms in JIA patients, but the mechanisms of action remain unclear. This review focuses on the mechanisms underlying exercise-induced immune and hormonal changes. Data on the impact of acute and chronic physical activities on the secretion of hormones and other molecules such as miRNA or peptides involved in the inflammatory process in JIA was compiled and summarized, and the key role of the biological effect of muscle-derived interleukin 6 in the exercise-induced modulation of pro/anti-inflammatory balance is addressed. We also go on to review the effect of training and type of exercise on cytokine response. This review highlights the beneficial effect of physical exercise in children with JIA and potential effect of exercise on the balance between pro- and anti-inflammatory response.
幼年特发性关节炎（JIA）是一种慢性炎症性疾病，其特征为持续的关节炎症，表现为关节疼痛和肿胀以及关节运动范围受限。在健康受试者中，文献报道身体活动具有抗炎作用。在 JIA 患者中，运动可以作为一种治疗工具来对抗与疾病相关的炎症，从而改善临床症状，尽管可能会出现短暂的疼痛加剧。实际上，在患有慢性炎症性疾病的患者中，身体活动容易加剧潜在的炎症应激。身体活动可改善 JIA 患者的生活质量和症状，但作用机制尚不清楚。这篇综述重点介绍了运动引起的免疫和激素变化的机制。我们编译和总结了关于急性和慢性身体活动对 JIA 患者炎症过程中涉及的激素和其他分子（如 miRNA 或肽）分泌的影响的数据，并探讨了肌肉衍生的白细胞介素 6 的生物学效应在运动诱导的促炎/抗炎平衡调节中的关键作用。我们还回顾了训练和运动类型对细胞因子反应的影响。本综述强调了身体活动对 JIA 儿童的有益影响，以及运动对促炎和抗炎反应平衡的潜在影响。
