Jaiswal P, Kumar K Jayaram
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, Jharkhand, India.
Int J Biol Macromol. 2015 Aug;79:256-61. doi: 10.1016/j.ijbiomac.2015.04.050. Epub 2015 Apr 29.
Many conventional sources of starches are from staple foods. Non-conventional and cheap sources of starch are being explored. Starch was isolated from Shahi Litchi seeds using two extraction media; acidic (citric acid 0.3%, w/w; LC) and alkaline (NaOH 0.5%, w/w; LN). Each starch was investigated for various properties such as structural, morphological and functional. The percentage yield of LN and LC was 11% and 12.6%, respectively. Morphological properties of both starches show same structural makeup, but compound granules were in LN starch. Moisture content, amylose content was found to be higher LC starch than in LN starch, which indicates that extraction media affects the properties of starch. FTIR confirmed the carbohydrate nature of the both isolated starches. TGA data of both starches reveal slight difference in stability with temperature. In vitro release of both starches shows the release up to 58.95±0.04% and 67.184±0.07% in 5h for LN and LC, respectively, that indicates that these starches can be used in delayed drug delivery and targeting drugs to the colon.
许多传统的淀粉来源都来自主食。人们正在探索非传统且廉价的淀粉来源。使用两种提取介质从沙希荔枝种子中分离出淀粉；酸性介质（柠檬酸0.3%，w/w；LC）和碱性介质（氢氧化钠0.5%，w/w；LN）。对每种淀粉的各种特性进行了研究，如结构、形态和功能特性。LN和LC的产率分别为11%和12.6%。两种淀粉的形态特性显示出相同的结构组成，但LN淀粉中有复合颗粒。发现LC淀粉的水分含量、直链淀粉含量高于LN淀粉，这表明提取介质会影响淀粉的特性。傅里叶变换红外光谱（FTIR）证实了两种分离出的淀粉的碳水化合物性质。两种淀粉的热重分析（TGA）数据显示在稳定性随温度变化方面存在细微差异。两种淀粉的体外释放率表明，LN和LC在5小时内分别释放高达58.95±0.04%和67.184±0.07%，这表明这些淀粉可用于延迟药物释放以及将药物靶向输送到结肠。
