Bagnato Francesca, Stern Barney J
Department of Neurology, University of Maryland, 110 S Paca St, Baltimore, MD 21201, USA.
Expert Rev Neurother. 2015 May;15(5):533-48. doi: 10.1586/14737175.2015.1037288.
Sarcoidosis is a multi-organ immune-mediated disease, which manifests as neurosarcoidosis (NS) in approximately 10% of all affected patients. The diagnosis of NS requires a high degree of suspicion as well as histological confirmation. Neurological symptoms in patients with systemic sarcoidosis should not be assumed to be due to NS unless proven true. The etiopathogenesis of NS is not yet fully elucidated and a reliable biomarker assessing disease progression is missing. As a probable result, there is no definitive cure for NS. The goals of available treatments include: halting inflammation, prevention of disease worsening and restoring neurological functions whenever possible. With immunosuppression, clinical remission of NS occurs in the majority of patients. However, in some others, the disease may still progress, as no permanent cure is yet available.
结节病是一种多器官免疫介导的疾病，在所有受影响的患者中，约10%会表现为神经结节病（NS）。NS的诊断需要高度怀疑以及组织学证实。除非得到证实，系统性结节病患者的神经症状不应被假定为由NS引起。NS的病因发病机制尚未完全阐明，且缺乏评估疾病进展的可靠生物标志物。可能正因如此，NS尚无确切的治愈方法。现有治疗的目标包括：停止炎症，预防疾病恶化，并尽可能恢复神经功能。通过免疫抑制，大多数NS患者会出现临床缓解。然而，在其他一些患者中，由于尚无永久治愈方法，疾病仍可能进展。
