Xiang Jing, Korostenskaja Milena, Molloy Cynthia, deGrauw Xinyao, Leiken Kimberly, Gilman Carley, Meinzen-Derr Jareen, Fujiwara Hisako, Rose Douglas F, Mitchell Terry, Murray Donna S
MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Functional Brain Mapping and Brain Computer Interface Lab, Comprehensive Pediatric Epilepsy Center, Center for Pediatric Research, Walt Disney Pavilion Florida Hospital for Children, Orlando, FL, USA.
Brain Dev. 2016 Jan;38(1):82-90. doi: 10.1016/j.braindev.2015.04.007. Epub 2015 Apr 27.
The abnormality of intrinsic brain activity in autism spectrum disorders (ASDs) is still inconclusive. Contradictory results have been found pointing towards hyper-activity or hypo-activity in various brain regions. The present research aims to investigate the spatial and spectral signatures of aberrant brain activity in an unprecedented frequency range of 1-2884 Hz at source levels in ASD using newly developed methods.
Seven ASD subjects and age- and gender-matched controls were studied using a high-sampling rate magnetoencephalography (MEG) system. Brain activity in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low gamma (30-55 Hz), high gamma (65-90 Hz), ripples (90-200 Hz), high-frequency oscillations (HFOs, 200-1000 Hz), and very high-frequency oscillations (VHFOs, 1000-2884 Hz) was volumetrically localized and measured using wavelet and beamforming.
In comparison to controls, ASD subjects had significantly higher odds of alpha activity (8-12 Hz) in the sensorimotor cortex (mu rhythm), and generally high-frequency activity (90-2884 Hz) in the frontal cortex. The source power of HFOs (200-1000 Hz) in the frontal cortex in ASD was significantly elevated as compared with controls.
The results suggest that ASD has significantly altered intrinsic brain activity in both low- and high-frequency ranges. Increased intrinsic high-frequency activity in the frontal cortex may play a key role in ASD.
自闭症谱系障碍（ASD）中大脑内在活动的异常仍无定论。已发现相互矛盾的结果，指向不同脑区的活动亢进或活动减退。本研究旨在使用新开发的方法，在ASD的源水平上，以前所未有的1 - 2884赫兹频率范围内研究异常脑活动的空间和频谱特征。
使用高采样率脑磁图（MEG）系统对7名ASD受试者以及年龄和性别匹配的对照组进行研究。使用小波和波束形成技术，对δ波（1 - 4赫兹）、θ波（4 - 8赫兹）、α波（8 - 12赫兹）、β波（12 - 30赫兹）、低伽马波（30 - 55赫兹）、高伽马波（65 - 90赫兹）、涟漪波（90 - 200赫兹）、高频振荡（HFOs，200 - 1000赫兹）和甚高频振荡（VHFOs，1000 - 2884赫兹）的脑活动进行体积定位和测量。
与对照组相比，ASD受试者在感觉运动皮层（μ节律）的α波活动（8 - 12赫兹）几率显著更高，并且额叶皮层普遍存在高频活动（90 - 2884赫兹）。与对照组相比，ASD患者额叶皮层中HFOs（200 - 1000赫兹）的源功率显著升高。
结果表明，ASD在低频和高频范围内均有显著改变的大脑内在活动。额叶皮层中内在高频活动的增加可能在ASD中起关键作用。
