Samoylov Ilya, Arcara Giorgio, Buyanova Irina, Davydova Elizaveta, Pereverzeva Darya, Sorokin Alexander, Tyushkevich Svetlana, Mamokhina Uliana, Danilina Kamilla, Dragoy Olga, Arutiunian Vardan
Center for Language and Brain, HSE University, Moscow, Russia.
IRCCS San Camillo Hospital, Venice, Italy.
Int J Psychophysiol. 2024 Sep;203:112405. doi: 10.1016/j.ijpsycho.2024.112405. Epub 2024 Jul 23.
Some studies have hypothesized that atypical neural synchronization at the delta frequency band in the auditory cortex is associated with phonological and language skills in children with Autism Spectrum Disorder (ASD), but it is still poorly understood. This study investigated this neural activity and addressed the relationships between auditory response and behavioral measures of children with ASD.
We used magnetoencephalography and individual brain models to investigate 2 Hz Auditory Steady-State Response (ASSR) in 20 primary-school-aged children with ASD and 20 age-matched typically developing (TD) controls.
First, we found a between-group difference in the localization of the auditory response, so as the topology of 2 Hz ASSR was more superior and posterior in TD children when comparing to children with ASD. Second, the power of 2 Hz ASSR was reduced in the ASD group. Finally, we observed a significant association between the amplitude of neural response and language skills in children with ASD.
The study provided the evidence of reduced neural response in children with ASD and its relation to language skills.
These findings may inform future interventions targeting auditory and language impairments in ASD population.
一些研究推测，自闭症谱系障碍（ASD）儿童听觉皮层中δ频段的非典型神经同步与语音和语言技能有关，但目前仍了解甚少。本研究调查了这种神经活动，并探讨了ASD儿童听觉反应与行为指标之间的关系。
我们使用脑磁图和个体脑模型，对20名小学年龄段的ASD儿童和20名年龄匹配的发育正常（TD）对照儿童的2赫兹听觉稳态反应（ASSR）进行了研究。
首先，我们发现听觉反应的定位存在组间差异，与ASD儿童相比，TD儿童中2赫兹ASSR的拓扑结构在更靠上和靠后的位置。其次，ASD组中2赫兹ASSR的功率降低。最后，我们观察到ASD儿童神经反应幅度与语言技能之间存在显著关联。
该研究提供了ASD儿童神经反应降低及其与语言技能关系的证据。
这些发现可能为未来针对ASD人群听觉和语言障碍的干预措施提供参考。
