Tsai Andrew, Malek-Ahmadi Michael, Kahlon Vickram, Sabbagh Marwan N
The Cleo Roberts Center for Clinical Research, Banner-Sun Health Research Institute, AZ, USA.
J Alzheimers Dis Parkinsonism. 2014 May 30;4(4). doi: 10.4172/2161-0460.1000150.
In the present study, cerebrospinal fluid (CSF) profiles were assessed to determine how idiopathic normal pressure hydrocephalus (NPH) and Alzheimer's disease (AD) differs.
Subjects were drawn from patients who underwent lumbar punctures as part of their diagnostic evaluations in the Banner Sun Health Research Institute Memory Disorders clinic. The clinical sample included 11 iNPH subjects (mean age 81.36±2.58) and 11 AD subjects (mean age 61.46±8.24). Concentrations of amyloid-β (Aβ42), total-tau (t-tau), phospho-tau181 (p-tau) Aβ42, and an Aβ42-Tau Index (ATI) were measured by commercial assay (Athena Diagnostics). and compared to each other. The Mann-Whitney test was used to assess group differences on the raw values for Aβ42, t-tau, p-tau, ATI, age, education, and MMSE.
In a univariate analysis, p-tau was found to be significantly (P = 0.009) lower in patients diagnosed with iNPH than those with AD. Amyloid-β (Aβ42), total-tau (t-tau) did not differ between groups. In multi-variate analysis, the differences in p-tau between groups did not differ.
Although age could represent a significant confound, p-tau is significantly lower in iNPH compared to AD. P-tau would be expected to increase with age but in this sample is lower suggesting the difference might be explained by the underlying condition.
在本研究中，评估脑脊液（CSF）特征以确定特发性正常压力脑积水（NPH）与阿尔茨海默病（AD）之间的差异。
研究对象来自班纳太阳健康研究所记忆障碍诊所接受腰椎穿刺作为诊断评估一部分的患者。临床样本包括11名特发性正常压力脑积水患者（平均年龄81.36±2.58岁）和11名阿尔茨海默病患者（平均年龄61.46±8.24岁）。通过商业检测法（雅典娜诊断公司）测量淀粉样蛋白β（Aβ42）、总tau蛋白（t-tau）、磷酸化tau181（p-tau）Aβ42和Aβ42 - Tau指数（ATI），并进行相互比较。采用曼 - 惠特尼检验评估Aβ42、t-tau、p-tau、ATI、年龄、教育程度和简易精神状态检查表（MMSE）原始值的组间差异。
在单变量分析中，发现被诊断为特发性正常压力脑积水的患者的p-tau显著低于阿尔茨海默病患者（P = 0.009）。淀粉样蛋白β（Aβ42）、总tau蛋白（t-tau）在两组之间没有差异。在多变量分析中，两组之间p-tau的差异没有变化。
尽管年龄可能是一个显著的混杂因素，但与阿尔茨海默病相比，特发性正常压力脑积水患者的p-tau显著较低。p-tau预计会随着年龄增长而增加，但在本样本中较低，这表明差异可能由潜在疾病解释。
