Nassar Basant R, Lippa Carol F
Drexel University, Philadelphia, PA, USA.
Gerontol Geriatr Med. 2016 Apr 20;2:2333721416643702. doi: 10.1177/2333721416643702. eCollection 2016 Jan-Dec.
Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed search engine of keywords "normal pressure hydrocephalus," "diagnosis," "shunt treatment," "biomarkers," "gait disturbances," "cognitive function," "neuropsychology," "imaging," and "pathogenesis," articles were obtained for this review. The majority of the articles were retrieved from the past 10 years. The purpose of this review article is to aid general practitioners in further understanding current findings on the pathogenesis, diagnosis, and treatment of iNPH.
特发性正常压力脑积水（iNPH）是一种潜在可逆的神经退行性疾病，通常以痴呆、步态和排尿障碍三联征为特征。诊断和治疗方面的进展有助于正确识别和改善患者症状。然而，很大一部分iNPH患者仍未得到诊断或被误诊。通过使用PubMed搜索引擎，以“正常压力脑积水”、“诊断”、“分流治疗”、“生物标志物”、“步态障碍”、“认知功能”、“神经心理学”、“影像学”和“发病机制”为关键词，获取了用于本综述的文章。大多数文章检索自过去10年。这篇综述文章的目的是帮助全科医生进一步了解iNPH发病机制、诊断和治疗的当前研究结果。
