儿童临床孤立综合征中的视觉通路受累情况。
Visual pathways involvement in clinically isolated syndrome in children.
作者信息
Voitenkov Vladislav, Skripchenko Natalia, Klimkin Andrey
机构信息
Scientific Research Institute of Children's Infections, Professora Popova 9, Saint-Petersburg 197122, Russia.
出版信息
Int J Ophthalmol. 2015 Apr 18;8(2):382-4. doi: 10.3980/j.issn.2222-3959.2015.02.30. eCollection 2015.
AIM
To investigate extent and nature of visual pathways involvement in children with clinically isolated syndrome (CIS).
METHODS
Forty-seven patients (age 11-17y) with CIS, which later proved to be multiple sclerosis (MS) onset, and 30 controls underwent visual evoked potentials (VEP) investigation within 12d from the appearance of the first signs of disease. Latency and amplitude of P100 peak were compared with normative data and between groups.
RESULTS
In 58% patients, including those without signs of retrobulbar neuritis, significant slowing of conduction along the central visual pathways (P100 latency lengthening) is seen. P100 amplitudes drop (signs of axonal damage) are registered less frequently (29% cases).
CONCLUSION
The results indicate that visual pathways are often affected in the MS onset; mostly demyelination signs are seen. Despite MRI significance for MS diagnostic, VEPs proved to be still effective in early diagnosis of MS in children.
目的
研究临床孤立综合征（CIS）患儿视觉通路受累的程度和性质。
方法
47例（年龄11 - 17岁）CIS患儿，后来被证实为多发性硬化症（MS）发病，以及30名对照者在疾病首次出现症状后的12天内接受了视觉诱发电位（VEP）检查。将P100波峰的潜伏期和波幅与正常数据进行比较，并在组间进行比较。
结果
在58%的患者中，包括那些没有球后视神经炎体征的患者，可见沿中枢视觉通路的传导明显减慢（P100潜伏期延长）。P100波幅下降（轴突损伤体征）的情况较少见（29%的病例）。
结论
结果表明，在MS发病时视觉通路常受影响；主要表现为脱髓鞘体征。尽管MRI对MS诊断有重要意义，但VEP在儿童MS的早期诊断中仍被证明是有效的。
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