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使用自体肝圆韧带瓣可消除肝门部胆管癌根治性切除术后的胆漏。

Use of an autologous liver round ligament flap zeros postoperative bile leak after curative resection of hilar cholangiocarcinoma.

作者信息

Sun Da-Xin, Tan Xiao-Dong, Gao Feng, Xu Jin, Cui Dong-Xu, Dai Xian-Wei

机构信息

Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110000, China.

出版信息

PLoS One. 2015 May 4;10(5):e0125977. doi: 10.1371/journal.pone.0125977. eCollection 2015.

Abstract

BACKGROUND

Postoperative bile leak is a major surgical morbidity after curative resection with hepaticojejunostomy for hilar cholangiocarcinoma, especially in Bismuth-Corlette types III and IV. This retrospective study assessed the effectiveness and safety of an autologous hepatic round ligament flap (AHRLF) for reducing bile leak after hilar hepaticojejunostomy.

METHODS

Nine type III and IV hilar cholangiocarcinoma patients were consecutively hospitalized for elective perihilar partial hepatectomy with hilar hepaticojejunostomy using an AHRLF between October 2009 and September 2013. The AHRLF was harvested to reinforce the perihilar hepaticojejunostomy. Main outcome measures included operative time, blood loss, postoperative recovery times, morbidity, bile leak, R0 resection rate, and overall survival.

RESULTS

All patients underwent uneventful R0 resection with hilar hepaticojejunostomy. No patient experienced postoperative bile leak.

CONCLUSIONS

The AHRLF was associated with lack of bile leak after curative perihilar hepatectomy with hepaticojejunostomy for hilar cholangiocarcinoma, without compromising oncologic safety, and is recommended in selected patients.

摘要

背景

术后胆漏是肝门部胆管癌根治性切除并肝管空肠吻合术后的主要手术并发症,尤其是在Bismuth-Corlette III型和IV型患者中。本回顾性研究评估了自体肝圆韧带瓣(AHRLF)在减少肝门部肝管空肠吻合术后胆漏方面的有效性和安全性。

方法

2009年10月至2013年9月期间,连续9例III型和IV型肝门部胆管癌患者因择期行肝门部部分肝切除术并使用AHRLF进行肝门部肝管空肠吻合而住院。采集AHRLF以加强肝门部肝管空肠吻合。主要观察指标包括手术时间、出血量、术后恢复时间、发病率、胆漏、R0切除率和总生存率。

结果

所有患者均顺利进行了肝门部肝管空肠吻合的R0切除。无患者发生术后胆漏。

结论

对于肝门部胆管癌行根治性肝门部肝切除并肝管空肠吻合术后,AHRLF与无胆漏相关,且不影响肿瘤学安全性,推荐用于特定患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d2a/4418604/13afcd3e2e9f/pone.0125977.g001.jpg

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