使用SnCl₂·2H₂O/PMHS/MeOH通过羰基化合物的化学选择性还原胺化反应合成叔胺
Chemoselective Reductive Amination of Carbonyl Compounds for the Synthesis of Tertiary Amines Using SnCl2·2H2O/PMHS/MeOH.
作者信息
Nayal Onkar S, Bhatt Vinod, Sharma Sushila, Kumar Neeraj
机构信息
†Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India.
‡Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India.
出版信息
J Org Chem. 2015 Jun 5;80(11):5912-8. doi: 10.1021/acs.joc.5b00156. Epub 2015 May 14.
Stannous chloride catalyzed chemoselective reductive amination of a variety of carbonyl compounds with aromatic amines has been developed for the synthesis of a diverse range of tertiary amines using inexpensive polymethylhydrosiloxane as reducing agent in methanol. The present method is also applicable for the synthesis of secondary amines including heterocyclic ones.
已开发出氯化亚锡催化多种羰基化合物与芳香胺的化学选择性还原胺化反应，以廉价的聚甲基氢硅氧烷为还原剂，在甲醇中合成多种叔胺。本方法也适用于仲胺（包括杂环仲胺）的合成。
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