Córdova-Pérez Nydia, Basurto-Acevedo Lourdes, Degollado-Córdova José Antonio, Saucedo-García Renata Patricia, Martínez-Murillo Carlos, Zárate-Treviño Arturo, Vázquez-Martínez Ana Laura, Vega-García Sara, Díaz-Martínez Alma Grisel, Borrayo-Sánchez Gabriela, Reyes-Maldonado Elba
Medical Research Unit in Endocrine Diseases, Hospital de Especialidades, Centro Médico Nacional, IMSS, Mexico.
National School of Biological Sciences, Instituto Politécnico Nacional, Mexico.
Rev Invest Clin. 2015 Mar-Apr;67(2):122-9.
PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels.
The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease.
A cross-sectional study was conducted in 142 women aged 45 to 60 years with no history of cardiovascular disease. Anthropometric and laboratory measurements were performed, including PAI-1 levels. All participants underwent a B-Mode ultrasound to measure intima-media thickness. Subclinical atherosclerosis was considered when intima-media thickness was ≥ 0.7 mm and/or an atheromatous plaque was observed.
Postmenopausal women had greater intima-media thickness than premenopausal women (0.688 ± 0.129 vs. 0.621 ± 0.113 mm; p < 0.05). Compared to women with normal intima-media thickness, women with subclinical atherosclerosis had higher PAI-1 levels (23.2 ± 13.7 vs. 30.4 ± 20.7 ng/ml; p < 0.05). In all participants, intima-media thickness correlated with PAI-1 (r = 0.302; p = 0.01) and with age (r = 0.358; p = 0001).
An increase in intima-media thickness was observed in postmenopausal women compared with premenopausal women. Asymptomatic women with increased intima-media thickness had higher PAI-1 levels. These findings suggest that fibrinolytic activity is low in the subclinical stage of atherosclerosis.
纤溶酶原激活物抑制剂-1（PAI-1）是纤维蛋白溶解的主要抑制剂。PAI-1水平升高与冠心病风险相关；然而，关于亚临床动脉粥样硬化与PAI-1水平之间关系的研究较少。
本研究旨在分析无明显心血管疾病的绝经前和绝经后女性中PAI-1水平与颈动脉内膜中层厚度之间的关系。
对142名年龄在45至60岁、无心血管疾病史的女性进行了一项横断面研究。进行了人体测量和实验室检测，包括PAI-1水平。所有参与者均接受B型超声检查以测量内膜中层厚度。当内膜中层厚度≥0.7mm和/或观察到动脉粥样斑块时，考虑为亚临床动脉粥样硬化。
绝经后女性的内膜中层厚度大于绝经前女性（0.688±0.129 vs. 0.621±0.113mm；p<0.05）。与内膜中层厚度正常的女性相比，患有亚临床动脉粥样硬化的女性PAI-1水平更高（23.2±13.7 vs. 30.4±20.7ng/ml；p<0.05）。在所有参与者中，内膜中层厚度与PAI-1相关（r = 0.302；p = 0.01），与年龄相关（r = 0.358；p = 0.001）。
与绝经前女性相比，绝经后女性的内膜中层厚度增加。内膜中层厚度增加的无症状女性PAI-1水平更高。这些发现表明，在动脉粥样硬化的亚临床阶段，纤维蛋白溶解活性较低。
