一种新型四齿钌（II）配合物，含有三（2-吡啶甲基）胺（tpa）作为β-淀粉样蛋白纤维化的抑制剂。
A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation.
作者信息
Chan Sharon Lai-Fung, Lu Lihua, Lam Tsz Lung, Yan Siu-Cheong, Leung Chung-Hang, Ma Dik-Lung
机构信息
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
出版信息
Curr Alzheimer Res. 2015;12(5):434-8. doi: 10.2174/1567205012666150504150726.
We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO(4) 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
我们在此报告一种新型四齿钌（II）配合物1的合成与应用，该配合物含有三（2-吡啶甲基）胺（tpa）配体，作为β-淀粉样蛋白纤维形成的抑制剂。[Ru（tpa）（bt）]ClO(4) 1（bt = 2-乙酰基苯并[b]噻吩-3-醇盐）在体外对Aβ(1-40)肽聚集表现出显著抑制作用，这通过硫黄素T测定法和透射电子显微镜成像得到证实。
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