发光铱（III）配合物探针抑制β-淀粉样蛋白纤维化
Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes.
作者信息
Lu Lihua, Zhong Hai-Jing, Wang Modi, Ho See-Lok, Li Hung-Wing, Leung Chung-Hang, Ma Dik-Lung
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
出版信息
Sci Rep. 2015 Sep 30;5:14619. doi: 10.1038/srep14619.
We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1-40 peptide on the basis of their emission response.
我们在此报告动力学惰性发光铱（III）配合物作为β-淀粉样蛋白纤维形成的双重抑制剂和探针的应用。这些铱（III）配合物在体外抑制Aβ1-40肽聚集，并保护神经元细胞免受Aβ诱导的细胞毒性。此外，这些配合物根据其发射响应区分Aβ1-40肽的聚集形式和未聚集形式。
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