Froeling Vera, Heimann Uwe, Huebner Ralf-Harto, Kroencke Thomas J, Maurer Martin H, Doellinger Felix, Geisel Dominik, Hamm Bernd, Brenner Winfried, Schreiter Nils F
Department of Radiology, Charité, Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany,
Ann Nucl Med. 2015 Jul;29(6):528-34. doi: 10.1007/s12149-015-0976-4. Epub 2015 May 5.
To evaluate the utility of attenuation correction (AC) of V/P SPECT images for patients with pulmonary emphysema.
Twenty-one patients (mean age 67.6 years) with pulmonary emphysema who underwent V/P SPECT/CT were included. AC/non-AC V/P SPECT images were compared visually and semiquantitatively. Visual comparison of AC/non-AC images was based on a 5-point likert scale. Semiquantitative comparison assessed absolute counts per lung (aCpLu) and lung lobe (aCpLo) for AC/non-AC images using software-based analysis; percentage counts (PC = (aCpLo/aCpLu) × 100) were calculated. Correlation between AC/non-AC V/P SPECT images was analyzed using Spearman's rho correlation coefficient; differences were tested for significance with the Wilcoxon rank sum test.
Visual analysis revealed high conformity for AC and non-AC V/P SPECT images. Semiquantitative analysis of PC in AC/non-AC images had an excellent correlation and showed no significant differences in perfusion (ρ = 0.986) or ventilation (ρ = 0.979, p = 0.809) SPECT/CT images.
AC of V/P SPECT images for lung lobe-based function imaging in patients with pulmonary emphysema do not improve visual or semiquantitative image analysis.
评估肺通气/灌注（V/P）单光子发射计算机断层扫描（SPECT）图像衰减校正（AC）对肺气肿患者的效用。
纳入21例接受V/P SPECT/CT检查的肺气肿患者（平均年龄67.6岁）。对AC/非AC V/P SPECT图像进行视觉和半定量比较。AC/非AC图像的视觉比较基于5级李克特量表。半定量比较使用基于软件的分析评估AC/非AC图像的每肺绝对计数（aCpLu）和肺叶绝对计数（aCpLo）；计算百分比计数（PC =（aCpLo/aCpLu）×100）。使用Spearman等级相关系数分析AC/非AC V/P SPECT图像之间的相关性；采用Wilcoxon秩和检验对差异进行显著性检验。
视觉分析显示AC和非AC V/P SPECT图像具有高度一致性。AC/非AC图像中PC的半定量分析具有良好的相关性，且在灌注（ρ = 0.986）或通气（ρ = 0.979，p = 0.809）SPECT/CT图像中无显著差异。
对于肺气肿患者基于肺叶的功能成像，V/P SPECT图像的AC并不能改善视觉或半定量图像分析。
