Filler Guido
Department of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada, N6A 5 W9,
Pediatr Nephrol. 2015 Aug;30(8):1209-12. doi: 10.1007/s00467-014-3014-1. Epub 2015 May 5.
In this edition of Pediatric Nephrology, Milena Treiber and colleagues have published a study on cystatin C (CysC) concentrations in relation to renal volumetry in 50 small-for-gestational age (SGA) and 50 appropriate-for-gestational age (AGA) neonates, deriving a new formula for estimating neonatal glomerular filtration rate (GFR). The study builds on previous work which established that renal volumetry together with CysC blood levels is a superior method for establishing GFR in term and pre-term newborns [The Journal of Pediatrics (2014) 164:1026-1031.e2]. Treiber et al. use the expected difference between SGA and AGA renal volumes to document the superiority of their new formula, which is based on total renal volume, CysC and body surface area, but does not incorporate gold-standard inulin clearance. Treiber et al.'s study adds new knowledge to the field that will hopefully improve the safety of renally excreted critical dose drugs in the newborn period. This editorial discusses the strengths and limitations of the current study.
在本期《儿科肾脏病学》中，米莱娜·特雷伯及其同事发表了一项关于50例小于胎龄（SGA）新生儿和50例适于胎龄（AGA）新生儿的胱抑素C（CysC）浓度与肾脏容积测定关系的研究，得出了一个估算新生儿肾小球滤过率（GFR）的新公式。该研究建立在先前的工作基础之上，先前的工作已确定，对于足月儿和早产儿，肾脏容积测定与CysC血水平相结合是建立GFR的一种更优方法[《儿科学杂志》（2014年）164:1026 - 1031.e2]。特雷伯等人利用SGA和AGA肾脏容积之间的预期差异来证明他们新公式的优越性，该公式基于肾脏总体积、CysC和体表面积，但未纳入金标准菊粉清除率。特雷伯等人的研究为该领域增添了新知识，有望提高新生儿期经肾脏排泄的关键剂量药物的安全性。本社论讨论了当前研究的优点和局限性。
