Kuriu Takayuki, Kakimoto Yuta, Araki Osamu
Department of Applied Physics, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo, 125-8585, Japan.
J Biol Phys. 2015 Sep;41(4):377-90. doi: 10.1007/s10867-015-9385-0. Epub 2015 May 5.
Although recent reports have suggested that synchronous neuronal UP states are mediated by astrocytic activity, the mechanism responsible for this remains unknown. Astrocytic glutamate release synchronously depolarizes adjacent neurons, while synaptic transmissions are blocked. The purpose of this study was to confirm that astrocytic depolarization, propagated through synaptic connections, can lead to synchronous neuronal UP states. We applied astrocytic currents to local neurons in a neural network consisting of model cortical neurons. Our results show that astrocytic depolarization may generate synchronous UP states for hundreds of milliseconds in neurons even if they do not directly receive glutamate release from the activated astrocyte.
尽管最近的报告表明同步神经元的UP状态是由星形胶质细胞活动介导的，但其背后的机制仍然未知。星形胶质细胞释放的谷氨酸会使相邻神经元同步去极化，同时突触传递被阻断。本研究的目的是证实通过突触连接传播的星形胶质细胞去极化可导致神经元同步的UP状态。我们将星形胶质细胞电流施加到由模型皮质神经元组成的神经网络中的局部神经元上。我们的结果表明，即使神经元没有直接接收到来自活化星形胶质细胞释放的谷氨酸，星形胶质细胞去极化也可能在神经元中产生数百毫秒的同步UP状态。
