Tewari Shivendra G, Majumdar Kaushik Kumar
Systems Science and Informatics Unit, Indian Statistical Institute, 8th Mile, Mysore Road, Bangalore, 560059 India ; Biotechnology & Bioengineering Center and Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA.
J Biol Phys. 2012 Jun;38(3):465-96. doi: 10.1007/s10867-012-9267-7. Epub 2012 May 27.
In this paper, we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and a peri-synaptic astrocyte controlling Ca(2 + ) dynamics inside the synaptic bouton. This in turn controls glutamate release dynamics in the cleft. As a consequence of this, glutamate concentration in the cleft has been modeled, in which glutamate reuptake by astrocytes has also been incorporated. Finally, dendritic spine-head dynamics has been modeled. As an application, this model clearly shows synaptic potentiation in the hippocampal region, i.e., astrocyte Ca(2 + ) mediates synaptic plasticity, which is in conformity with the majority of the recent findings (Perea and Araque (Science 317, 1083-1086, 2007); Henneberger et al. (Nature 463, 232-236, 2010); Navarrete et al. (PLoS Biol. 10, e1001259, 2012)).
在本文中，我们提出了一个三方突触的生物学详细数学模型，其中星形胶质细胞调节短期突触可塑性。该模型由一个突触前终扣、一个突触后树突棘头、一个突触间隙和一个控制突触终扣内Ca(2+)动态的突触周围星形胶质细胞组成。这反过来又控制了间隙中谷氨酸的释放动态。因此，对间隙中的谷氨酸浓度进行了建模，其中还纳入了星形胶质细胞对谷氨酸的再摄取。最后，对树突棘头动态进行了建模。作为一个应用，该模型清楚地显示了海马区的突触增强，即星形胶质细胞Ca(2+)介导突触可塑性，这与大多数最新研究结果一致（佩雷亚和阿雷克（《科学》317卷，1083 - 1086页，2007年）；亨内贝格尔等人（《自然》463卷，232 - 236页，2010年）；纳瓦雷特等人（《公共科学图书馆·生物学》10卷，e1001259，2012年））。
