通过串联铜催化环加成反应和铑催化的炔烃、N-磺酰基叠氮化物及芳基醚的烷氧基芳基化反应合成2-烷氧基芳基-2-芳基烯胺
Synthesis of 2-Alkoxyaryl-2-aryl Enamines via Tandem Copper-Catalyzed Cycloaddition and Rhodium-Catalyzed Alkoxyarylation from Alkynes, N-Sulfonyl Azides, and Aryl Ethers.
作者信息
Shin Seohyun, Park Youngchul, Kim Cheol-Eui, Son Jeong-Yu, Lee Phil Ho
机构信息
National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.
出版信息
J Org Chem. 2015 Jun 5;80(11):5859-69. doi: 10.1021/acs.joc.5b00891. Epub 2015 May 15.
A synthetic route to a wide range of 2-alkoxyaryl-2-aryl enamines is developed from Rh-catalyzed alkoxyarylation of N-sulfonyl-4-aryl-1,2,3-triazoles with aryl ethers via the elimination of nitrogen molecule. In addition, 2-alkoxyaryl-2-aryl enamines are prepared via tandem Cu-catalyzed cycloaddition and Rh-catalyzed alkoxyarylation starting from alkynes, N-sulfonyl azides, and aryl ethers in one-pot.
通过消除氮分子，由铑催化的N-磺酰基-4-芳基-1,2,3-三唑与芳基醚的烷氧基芳基化反应，开发出了一条合成多种2-烷氧基芳基-2-芳基烯胺的路线。此外，从炔烃、N-磺酰基叠氮化物和芳基醚一锅法出发，通过串联铜催化的环加成反应和铑催化的烷氧基芳基化反应制备了2-烷氧基芳基-2-芳基烯胺。
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