Kruszynski Rafal, Czestkowski Wojciech
Institute of General and Ecological Chemistry, Lodz University of Technology, ul. Zeromskiego 116, 90-924 Lodz, Poland.
Institute of Organic Chemistry, Lodz University of Technology, ul. Zeromskiego 116, 90-924 Lodz, Poland.
Acta Crystallogr C Struct Chem. 2015 May;71(Pt 5):402-6. doi: 10.1107/S2053229615006646. Epub 2015 Apr 15.
The title compound, C21H26FN3O7, is assembled by N-H...O and O-H...O hydrogen bonds into well-separated two-dimensional layers of about 15 Å thickness. The crescent conformation of the molecules is stabilized by weak intramolecular C-H...O and C-H...F hydrogen bonds. The uridine moiety adopts an anti conformation. The ribofuranose ring exists in an envelope conformation. All the endocyclic uracil bonds are shorter than normal single C-N and C-C bonds, and five of them have comparable lengths, which implies a considerable degree of delocalization of the electron density within this ring.
标题化合物C21H26FN3O7通过N-H…O和O-H…O氢键组装成厚度约为15 Å的分离良好的二维层。分子的月牙形构象通过弱分子内C-H…O和C-H…F氢键得以稳定。尿苷部分呈反式构象。呋喃核糖环以信封式构象存在。所有环内尿嘧啶键均短于正常的单C-N和C-C键，其中五个键长度相当，这意味着该环内电子密度有相当程度的离域。
