血管紧张素转换酶2-血管紧张素-（1-7）-Mas轴可能是肺动脉高压一个有前景的治疗靶点。 - Suppr

ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension.

作者信息

Dai Hailong, Jiang Lihong, Xiao Zhicheng, Guang Xuefeng

机构信息

Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, 245 East Renming Road, Kunming 650051, People's Republic of China.

Department of Cardiothoracic Surgery, Yan'an Affiliated Hospital of Kunming Medical University, 245 East Renming Road, Kunming 650051, People's Republic of China.

出版信息

Nat Rev Cardiol. 2015 Jun;12(6):374. doi: 10.1038/nrcardio.2015.6-c1. Epub 2015 May 5.

DOI:10.1038/nrcardio.2015.6-c1

PMID:25940924

Abstract

摘要

相似文献

ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension.血管紧张素转换酶2-血管紧张素-（1-7）-Mas轴可能是肺动脉高压一个有前景的治疗靶点。

Nat Rev Cardiol. 2015 Jun;12(6):374. doi: 10.1038/nrcardio.2015.6-c1. Epub 2015 May 5.

[Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension].[血管紧张素转换酶2-血管紧张素（1-7）-Mas受体轴在射血分数保留的心力衰竭合并高血压中的作用]

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018 Jul 28;43(7):738-746. doi: 10.11817/j.issn.1672-7347.2018.07.007.

Captopril improves postresuscitation hemodynamics protective against pulmonary embolism by activating the ACE2/Ang-(1-7)/Mas axis.卡托普利通过激活ACE2/血管紧张素-(1-7)/Mas轴改善复苏后血流动力学，对肺栓塞具有保护作用。

Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1159-1169. doi: 10.1007/s00210-016-1278-7. Epub 2016 Jul 22.

The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.先天性心脏病所致肺动脉高压患者血清血管紧张素转换酶2的变化

Cardiology. 2013;124(4):208-12. doi: 10.1159/000346884. Epub 2013 Mar 20.

The Anti-Inflammatory Potential of ACE2/Angiotensin-(1-7)/Mas Receptor Axis: Evidence from Basic and Clinical Research.ACE2/血管紧张素-(1-7)/Mas 受体轴的抗炎潜力：基础与临床研究证据。

Curr Drug Targets. 2017;18(11):1301-1313. doi: 10.2174/1389450117666160727142401.

Angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis protects against lung fibrosis by inhibiting the MAPK/NF-κB pathway.血管紧张素转换酶 2/血管紧张素-(1-7)/Mas 轴通过抑制 MAPK/NF-κB 通路来保护肺纤维化。

Am J Respir Cell Mol Biol. 2014 Apr;50(4):723-36. doi: 10.1165/rcmb.2012-0451OC.

Protective role of ACE2-Ang-(1-7)-Mas in myocardial fibrosis by downregulating K3.1 channel via ERK1/2 pathway.ACE2-Ang-(1-7)-Mas通过ERK1/2途径下调K3.1通道在心肌纤维化中的保护作用。

Pflugers Arch. 2016 Nov;468(11-12):2041-2051. doi: 10.1007/s00424-016-1875-9. Epub 2016 Sep 3.

Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases.将血管紧张素转换酶2作为心血管疾病的新治疗靶点。

Can J Physiol Pharmacol. 2014 Jul;92(7):558-65. doi: 10.1139/cjpp-2013-0488. Epub 2014 Apr 8.

[The ACE2/Ang(1-7)/Mas receptor axis in cardiovascular and renal diseases].[心血管和肾脏疾病中的ACE2/血管紧张素（1-7）/Mas受体轴]

Nihon Rinsho. 2012 Sep;70(9):1487-91.

ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease.ACE2-血管紧张素-(1-7)-Mas 轴与心血管疾病中的氧化应激。

Hypertens Res. 2011 Feb;34(2):154-60. doi: 10.1038/hr.2010.235. Epub 2010 Dec 2.

引用本文的文献

ACE2, a therapeutic target of COVID-19, needs to be treated with caution.血管紧张素转换酶2（ACE2）作为新型冠状病毒肺炎（COVID-19）的一个治疗靶点，需要谨慎对待。

Arch Virol. 2025 May 29;170(7):143. doi: 10.1007/s00705-025-06327-0.

Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like.血管紧张素转换酶 2 的泛素化有助于神经前体细胞表达发育下调基因 4 样物介导的肺动脉高压的发展。

Respir Res. 2024 Aug 29;25(1):326. doi: 10.1186/s12931-024-02953-5.

ACE2: the node connecting the lung cancer and COVID-19.血管紧张素转换酶2：连接肺癌与2019冠状病毒病的节点

Am J Cancer Res. 2024 Apr 15;14(4):1466-1481. doi: 10.62347/XJVE4569. eCollection 2024.

Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors.肾去神经支配影响血管紧张素II 1型和2型受体。

Int J Nephrol. 2022 Oct 10;2022:8731357. doi: 10.1155/2022/8731357. eCollection 2022.

Neuropathies and neurological dysfunction induced by coronaviruses.由冠状病毒引起的神经病变和神经功能障碍。

J Neurovirol. 2021 Jun;27(3):380-396. doi: 10.1007/s13365-021-00977-x. Epub 2021 May 13.

Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition.血管紧张素转换酶2激活剂改善左肺切除联合血管内皮生长因子抑制大鼠模型中的重度肺动脉高压

Front Med (Lausanne). 2021 Feb 19;8:619133. doi: 10.3389/fmed.2021.619133. eCollection 2021.

Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.使用COVID-19临床前模型的病理生理学及潜在的未来治疗靶点

ERJ Open Res. 2020 Dec 7;6(4). doi: 10.1183/23120541.00405-2020. eCollection 2020 Oct.

Emerging therapies for right ventricular dysfunction and failure.右心室功能障碍与衰竭的新兴疗法。

Cardiovasc Diagn Ther. 2020 Oct;10(5):1735-1767. doi: 10.21037/cdt-20-592.

Alteration in angiotensin-converting enzyme 2 by PM during the development of emphysema in rats.颗粒物在大鼠肺气肿发展过程中对血管紧张素转换酶2的影响。

ERJ Open Res. 2020 Oct 5;6(4). doi: 10.1183/23120541.00174-2020. eCollection 2020 Oct.

The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction.血管紧张素转化酶 2（ACE2）激活剂对左心功能障碍性肺动脉高压的有益作用。

Int J Med Sci. 2020 Sep 16;17(16):2594-2602. doi: 10.7150/ijms.48096. eCollection 2020.

本文引用的文献

Treatment of pulmonary arterial hypertension in children.儿童肺动脉高压的治疗。

Nat Rev Cardiol. 2015 Apr;12(4):244-54. doi: 10.1038/nrcardio.2015.6. Epub 2015 Feb 3.

Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.口服封装于植物细胞中的血管紧张素转换酶2和血管紧张素-（1-7）可减轻肺动脉高压。

Hypertension. 2014 Dec;64(6):1248-59. doi: 10.1161/HYPERTENSIONAHA.114.03871. Epub 2014 Sep 15.

Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants.

Hypertension. 2014 Dec;64(6):1182-3. doi: 10.1161/HYPERTENSIONAHA.114.04075. Epub 2014 Sep 15.

Decreased levels of serum Angiotensin-(1-7) in patients with pulmonary arterial hypertension due to congenital heart disease.先天性心脏病所致肺动脉高压患者血清血管紧张素 -（1 - 7）水平降低。

Int J Cardiol. 2014 Oct 20;176(3):1399-401. doi: 10.1016/j.ijcard.2014.08.021. Epub 2014 Aug 8.

ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.ACE2 激活赋予血管内皮保护作用，并减轻大鼠肺动脉高压预防中的内膜新生病变。

Lung. 2013 Aug;191(4):327-36. doi: 10.1007/s00408-013-9470-8. Epub 2013 May 8.

Cardiology. 2013;124(4):208-12. doi: 10.1159/000346884. Epub 2013 Mar 20.

Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.地美硝唑减轻肺动脉高压并改善实验模型中血管生成祖细胞的功能。

Am J Respir Crit Care Med. 2013 Mar 15;187(6):648-57. doi: 10.1164/rccm.201205-0880OC. Epub 2013 Jan 31.

Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.血管紧张素转换酶 2 激活通过改善早期内皮功能和调节细胞因子水平来预防肺动脉高压。

Chin Med J (Engl). 2012 Apr;125(8):1381-8.

Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia.重组血管紧张素转换酶2可抑制急性低氧时的肺血管收缩。

Wilderness Environ Med. 2012 Mar;23(1):24-30. doi: 10.1016/j.wem.2011.09.002.

The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.血管紧张素转化酶 2/血管生成素-(1-7)/Mas 轴赋予心肺对肺纤维化和肺动脉高压的保护作用。

Am J Respir Crit Care Med. 2010 Oct 15;182(8):1065-72. doi: 10.1164/rccm.200912-1840OC. Epub 2010 Jun 25.

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ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension.

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