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ACE2-angiotensin-(1-7)-Mas axis might be a promising therapeutic target for pulmonary arterial hypertension.

作者信息

Dai Hailong, Jiang Lihong, Xiao Zhicheng, Guang Xuefeng

机构信息

Department of Cardiology, Yan'an Affiliated Hospital of Kunming Medical University, 245 East Renming Road, Kunming 650051, People's Republic of China.

Department of Cardiothoracic Surgery, Yan'an Affiliated Hospital of Kunming Medical University, 245 East Renming Road, Kunming 650051, People's Republic of China.

出版信息

Nat Rev Cardiol. 2015 Jun;12(6):374. doi: 10.1038/nrcardio.2015.6-c1. Epub 2015 May 5.

DOI:10.1038/nrcardio.2015.6-c1
PMID:25940924
Abstract
摘要

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本文引用的文献

1
Treatment of pulmonary arterial hypertension in children.儿童肺动脉高压的治疗。
Nat Rev Cardiol. 2015 Apr;12(4):244-54. doi: 10.1038/nrcardio.2015.6. Epub 2015 Feb 3.
2
Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.口服封装于植物细胞中的血管紧张素转换酶2和血管紧张素-（1-7）可减轻肺动脉高压。
Hypertension. 2014 Dec;64(6):1248-59. doi: 10.1161/HYPERTENSIONAHA.114.03871. Epub 2014 Sep 15.
3
Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants.
血管紧张素转换酶2：连接肺癌与2019冠状病毒病的节点
Am J Cancer Res. 2024 Apr 15;14(4):1466-1481. doi: 10.62347/XJVE4569. eCollection 2024.
4
Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors.肾去神经支配影响血管紧张素II 1型和2型受体。
Int J Nephrol. 2022 Oct 10;2022:8731357. doi: 10.1155/2022/8731357. eCollection 2022.
5
Neuropathies and neurological dysfunction induced by coronaviruses.由冠状病毒引起的神经病变和神经功能障碍。
J Neurovirol. 2021 Jun;27(3):380-396. doi: 10.1007/s13365-021-00977-x. Epub 2021 May 13.
6
Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition.血管紧张素转换酶2激活剂改善左肺切除联合血管内皮生长因子抑制大鼠模型中的重度肺动脉高压
Front Med (Lausanne). 2021 Feb 19;8:619133. doi: 10.3389/fmed.2021.619133. eCollection 2021.
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Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.使用COVID-19临床前模型的病理生理学及潜在的未来治疗靶点
ERJ Open Res. 2020 Dec 7;6(4). doi: 10.1183/23120541.00405-2020. eCollection 2020 Oct.
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Emerging therapies for right ventricular dysfunction and failure.右心室功能障碍与衰竭的新兴疗法。
Cardiovasc Diagn Ther. 2020 Oct;10(5):1735-1767. doi: 10.21037/cdt-20-592.
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ERJ Open Res. 2020 Oct 5;6(4). doi: 10.1183/23120541.00174-2020. eCollection 2020 Oct.
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Lung. 2013 Aug;191(4):327-36. doi: 10.1007/s00408-013-9470-8. Epub 2013 May 8.
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Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia.重组血管紧张素转换酶2可抑制急性低氧时的肺血管收缩。
Wilderness Environ Med. 2012 Mar;23(1):24-30. doi: 10.1016/j.wem.2011.09.002.
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The angiotensin-converting enzyme 2/angiogenesis-(1-7)/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension.血管紧张素转化酶 2/血管生成素-(1-7)/Mas 轴赋予心肺对肺纤维化和肺动脉高压的保护作用。
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