免疫学到的经验教训：IL4R 直接促进乳腺肿瘤转移。
Lessons from immunology: IL4R directly promotes mammary tumor metastasis.
机构信息
Department of Cancer Biology; Vanderbilt University School of Medicine ; Nashville, TN USA.
出版信息
Oncoimmunology. 2014 Dec 13;3(9):e955373. doi: 10.4161/21624011.2014.955373. eCollection 2014 Oct.
Abstract
Interleukin-4 (IL4), a Th2 cytokine, signals through IL4 receptors (IL4Rs) to regulate increased lymphocyte proliferation and survival. We have recently discovered that IL4 also promotes these phenotypes in mammary cancer cells expressing IL4Rs to enhance their metastatic ability. Targeting IL4/IL4R signaling on cancer cells themselves may limit metastatic disease.
摘要
白细胞介素-4（IL-4）是一种 Th2 细胞因子，通过 IL-4 受体（IL-4R）信号传导来调节淋巴细胞增殖和存活的增加。我们最近发现，IL-4 还可促进表达 IL-4R 的乳腺癌细胞中出现这些表型，从而增强其转移能力。针对癌细胞自身的 IL-4/IL-4R 信号可能会限制转移性疾病。
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