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A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia.

作者信息

Gocho Y, Kiyokawa N, Ichikawa H, Nakabayashi K, Osumi T, Ishibashi T, Ueno H, Terada K, Oboki K, Sakamoto H, Shioda Y, Imai M, Noguchi Y, Arakawa Y, Kojima Y, Toyama D, Hata K, Yoshida T, Matsumoto K, Kato M, Fukushima T, Koh K, Manabe A, Ohara A

机构信息

Department of Pediatric Hematology and Oncology Research, National Research Institute for Child Health and Development, Setagaya-ku, Tokyo, Japan.

Department of Pediatrics, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.

出版信息

Leukemia. 2015 Dec;29(12):2445-8. doi: 10.1038/leu.2015.111. Epub 2015 May 6.

DOI:10.1038/leu.2015.111
PMID:25943178
Abstract
摘要

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A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia.B细胞前体急性淋巴细胞白血病中一种新的复发性EP300-ZNF384基因融合
Leukemia. 2015 Dec;29(12):2445-8. doi: 10.1038/leu.2015.111. Epub 2015 May 6.
2
EP300-ZNF384 fusion gene product up-regulates GATA3 gene expression and induces hematopoietic stem cell gene expression signature in B-cell precursor acute lymphoblastic leukemia cells.EP300-ZNF384融合基因产物上调GATA3基因表达,并在B细胞前体急性淋巴细胞白血病细胞中诱导造血干细胞基因表达特征。
Int J Hematol. 2017 Aug;106(2):269-281. doi: 10.1007/s12185-017-2220-6. Epub 2017 Apr 4.
3
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Clin Lab. 2024 Jun 1;70(6). doi: 10.7754/Clin.Lab.2023.231226.
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Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression.Pre-B 急性淋巴细胞白血病复发融合基因 EP300-ZNF384 与独特的基因表达相关。
Br J Cancer. 2018 Apr;118(7):1000-1004. doi: 10.1038/s41416-018-0022-0. Epub 2018 Mar 13.
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ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype.ZNF384相关融合基因定义了具有特征性免疫表型的儿童B细胞前体急性淋巴细胞白血病亚组。
Haematologica. 2017 Jan;102(1):118-129. doi: 10.3324/haematol.2016.151035. Epub 2016 Sep 15.
6
Detection of EP300-ZNF384 fusion in patients with acute lymphoblastic leukemia using RNA fusion gene panel sequencing.利用 RNA 融合基因 panel 测序检测急性淋巴细胞白血病患者中的 EP300-ZNF384 融合。
Ann Hematol. 2020 Nov;99(11):2611-2617. doi: 10.1007/s00277-020-04251-8. Epub 2020 Sep 26.
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Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.全转录组测序鉴定出一种急性淋巴细胞白血病的独特亚型,其主要基因组异常为EP300和CREBBP。
Genome Res. 2017 Feb;27(2):185-195. doi: 10.1101/gr.209163.116. Epub 2016 Nov 30.
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Detection of a Cryptic EP300/ZNF384 Gene Fusion by Chromosomal Microarray and Next-Generation Sequencing Studies in a Pediatric Patient with B-Lymphoblastic Leukemia.通过染色体微阵列和下一代测序研究在小儿 B 淋巴细胞白血病患者中检测到隐匿性 EP300/ZNF384 基因融合。
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Frequency and outcome of pediatric acute lymphoblastic leukemia with ZNF384 gene rearrangements including a novel translocation resulting in an ARID1B/ZNF384 gene fusion.伴有ZNF384基因重排的儿童急性淋巴细胞白血病的频率和结局,包括一种导致ARID1B/ZNF384基因融合的新型易位。
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[Analysis of Clinical Characteristics of Acute B Lymphoblastic Leukemia with EP300-ZNF384 Fusion Gene Positive].[EP300-ZNF384融合基因阳性急性B淋巴细胞白血病的临床特征分析]
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EP300-ZNF384 transactivates IL3RA to promote the progression of B-cell acute lymphoblastic leukemia.EP300-ZNF384 转录激活 IL3RA 促进 B 细胞急性淋巴细胞白血病进展。

本文引用的文献

1
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.Ph 样急性淋巴细胞白血病中可靶向的激酶激活病变。
N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088.
2
RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib.RNA测序鉴定出白血病中与临床相关的融合基因,包括一种对伊马替尼有反应的新型MEF2D/CSF1R融合基因。
Leukemia. 2014 Apr;28(4):977-9. doi: 10.1038/leu.2013.324. Epub 2013 Nov 4.
3
Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation.
Cell Commun Signal. 2024 Apr 2;22(1):211. doi: 10.1186/s12964-024-01596-9.
4
Targeted characterization of fusion transcripts in tumor and normal tissues via FusionInspector.通过 FusionInspector 对肿瘤和正常组织中的融合转录本进行靶向特征分析。
Cell Rep Methods. 2023 May 8;3(5):100467. doi: 10.1016/j.crmeth.2023.100467. eCollection 2023 May 22.
5
ZNF384-Related Fusion Genes in Acute Lymphoblastic Leukemia.急性淋巴细胞白血病中的 ZNF384 相关融合基因。
Cancer Control. 2023 Jan-Dec;30:10732748231182787. doi: 10.1177/10732748231182787.
6
MD-ALL: an Integrative Platform for Molecular Diagnosis of B-cell Acute Lymphoblastic Leukemia.MD-ALL:B 细胞急性淋巴细胞白血病分子诊断的综合平台
Res Sq. 2023 Apr 14:rs.3.rs-2798895. doi: 10.21203/rs.3.rs-2798895/v1.
7
Optical Genome Mapping Reveals and Characterizes Recurrent Aberrations and New Fusion Genes in Adult ALL.光学基因组图谱揭示并分析了成人 ALL 中的重现性畸变和新融合基因。
Genes (Basel). 2023 Mar 9;14(3):686. doi: 10.3390/genes14030686.
8
The Role of CREBBP/EP300 and Its Therapeutic Implications in Hematological Malignancies.CREBBP/EP300的作用及其在血液系统恶性肿瘤中的治疗意义
Cancers (Basel). 2023 Feb 14;15(4):1219. doi: 10.3390/cancers15041219.
9
RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL).RaScALL:用于急性淋巴细胞白血病(ALL)中具有预后意义的基因组改变的 RNA-seq 数据的快速(Ra)筛选(Sc)。
PLoS Genet. 2022 Oct 17;18(10):e1010300. doi: 10.1371/journal.pgen.1010300. eCollection 2022 Oct.
10
Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia.成人性 B 细胞急性淋巴细胞白血病中的致癌病变和分子亚型。
Cancer Sci. 2023 Jan;114(1):8-15. doi: 10.1111/cas.15583. Epub 2022 Sep 27.
p300 催化核心的结构及其对染色质靶向和 HAT 调节的影响。
Nat Struct Mol Biol. 2013 Sep;20(9):1040-6. doi: 10.1038/nsmb.2642. Epub 2013 Aug 11.
4
Acute lymphoblastic leukaemia.急性淋巴细胞白血病。
Lancet. 2013 Jun 1;381(9881):1943-55. doi: 10.1016/S0140-6736(12)62187-4. Epub 2013 Mar 22.
5
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia.高危急性淋巴细胞白血病中激活激酶和细胞因子受体信号的遗传改变。
Cancer Cell. 2012 Aug 14;22(2):153-66. doi: 10.1016/j.ccr.2012.06.005.
6
Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?小儿急性淋巴细胞白血病:我们将去向何方,又该如何到达那里?
Blood. 2012 Aug 9;120(6):1165-74. doi: 10.1182/blood-2012-05-378943. Epub 2012 Jun 22.
7
Inactivating mutations of acetyltransferase genes in B-cell lymphoma.B 细胞淋巴瘤中乙酰转移酶基因的失活突变。
Nature. 2011 Mar 10;471(7337):189-95. doi: 10.1038/nature09730.
8
Systematic in vivo structure-function analysis of p300 in hematopoiesis.体内造血系统中 p300 的系统结构-功能分析。
Blood. 2009 Nov 26;114(23):4804-12. doi: 10.1182/blood-2009-04-217794. Epub 2009 Oct 12.
9
Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia: the Tokyo Children's Cancer Study Group Study L99-15.泼尼松龙治疗7天后外周原始细胞完全清除在儿童急性淋巴细胞白血病中的意义:东京儿童癌症研究组L99-15研究
Haematologica. 2008 Aug;93(8):1155-60. doi: 10.3324/haematol.12365. Epub 2008 Jun 2.
10
E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia.急性白血病中由隐匿性t(12;19)(p13.3;p13.3)产生的E2A-ZNF384和NOL1-E2A融合基因。
Leukemia. 2008 Apr;22(4):723-9. doi: 10.1038/sj.leu.2405084. Epub 2008 Jan 10.