Zinc finger protein 384 () encodes a C2H2-type zinc finger protein that can function as a transcription factor. ZNF384 rearrangement in acute lymphoblastic leukemia (ALL) was first reported in 2002. More than 19 different ZNF384 fusion partners have been detected in ALL. These include E1A-binding protein P300 (), CREB-binding protein (), transcription factor 3 (), TATA-box binding protein associated factor 15 (), Ewing sarcoma breakpoint region 1 gene (), AT-rich interactive domain-containing protein 1B (), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4 (), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 2 (), synergin gamma (), clathrin heavy chain (), bone morphogenic protein 2-inducible kinase (), Nipped-B-like protein (), A Kinase Anchoring Protein 8 (), Chromosome 11 Open Reading Frame 74 (), DEAD-Box Helicase 42 (), ATP Synthase F1 Subunit Gamma (), Euchromatic Histone Lysine Methyltransferase 1 (), Testic Expressed 41 (), etc. Patients diagnosed with ALL harboring ZNF384 rearrangements commonly had a good prognosis. The mechanisms, performance, and features of different ZNF384 rearrangements in acute lymphoblastic leukemia have been well evaluated.