Zakaria Mohamed B, Belik Alexei A, Liu Chia-Hung, Hsieh Han-Yun, Liao Yu-Te, Malgras Victor, Yamauchi Yusuke, Wu Kevin C-W
Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo, 169-8555, Japan.
World Premier International (WPI) Research Center for Materials, Nanoarchitechtonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Chem Asian J. 2015 Jul;10(7):1457-62. doi: 10.1002/asia.201500232. Epub 2015 Jun 11.
New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.
通过热转化法成功地从普鲁士蓝（PB）纳米立方体合成了具有超顺磁行为的新型纳米多孔氧化铁纳米颗粒，并将其应用于具有控释和磁导向特性的膀胱癌细胞（即T24）的细胞内药物递送系统（DDS）。MTT分析和共聚焦激光扫描显微镜的结果表明，合成的氧化铁纳米颗粒被T24细胞成功摄取，具有优异的生物相容性。使用一种抗癌药物顺铂作为模型药物，并研究了其负载/释放行为。与无药物情况相比，顺铂负载的、PB衍生的、磁导向药物递送系统的细胞内药物递送效率大大提高。合成的纳米材料作为具有高生物相容性、控释和磁靶向特性的药物载体，在未来的细胞内DDS中显示出巨大的潜力。
