Xue Peng, Bao Jingnan, Wu Yafeng, Zhang Yilei, Kang Yuejun
J Nanosci Nanotechnol. 2017 Jan;17(1):168-74. doi: 10.1166/jnn.2017.12408.
Nanomaterial-based photothermal agents have attracted great attention as near-infrared laser driven ablation agents for tumor therapy. In this work, Prussian blue nanocubes with porous interior were synthesized via controlled chemical etching method and successfully applied for efficient photothermal ablation of tumor cells in vitro. Monodispersed porous Prussian blue nanocubes (115.4±4.7 nm) were produced through a controlled self-etching reaction in the presence of polyvinylpyrrolidone (PVP). Owing to the strong absorbance in near infrared (NIR) region, the resulted porous Prussian blue nanocubes could lead to more than 80% death of Hela cells after being treated with nanocubes of concentration as low as 100 μg mL−1. Compared to the traditional solid Prussian blue nanoparticles, these porous nanocubes can provide extra space for encapsulating anti-cancer drugs in their porous interior. It is anticipated that these porous Prussian blue nanocubes can be applied as an enabling platform to develop the next generation of multifunctional drug carrier for cancer treatments.
基于纳米材料的光热剂作为用于肿瘤治疗的近红外激光驱动消融剂受到了极大关注。在这项工作中，通过可控化学蚀刻法合成了内部具有多孔结构的普鲁士蓝纳米立方体，并成功将其应用于体外高效光热消融肿瘤细胞。在聚乙烯吡咯烷酮（PVP）存在的情况下，通过可控的自蚀刻反应制备了单分散的多孔普鲁士蓝纳米立方体（115.4±4.7纳米）。由于在近红外（NIR）区域有很强的吸收，所得的多孔普鲁士蓝纳米立方体在浓度低至100μg mL−1的纳米立方体处理后可导致超过80%的Hela细胞死亡。与传统的固体普鲁士蓝纳米颗粒相比，这些多孔纳米立方体可以在其多孔内部提供额外空间用于封装抗癌药物。预计这些多孔普鲁士蓝纳米立方体可作为一个赋能平台，用于开发下一代用于癌症治疗的多功能药物载体。
