Management of venous thromboembolism in patients with acute leukemia at high bleeding risk: a multi-center study.
作者信息
Napolitano Mariasanta, Valore Luca, Malato Alessandra, Saccullo Giorgia, Vetro Calogero, Mitra Maria Enza, Fabbiano Francesco, Mannina Donato, Casuccio Alessandra, Lucchesi Alessandro, Del Principe Maria Ilaria, Candoni Anna, Di Raimondo Francesco, Siragusa Sergio
机构信息
a Hematoloy Unit & Thrombosis and Hemostasis Reference Regional Center, University of Palermo , Palermo , Italy.
b Hematology Unit, General Hospital "Cervello" , Palermo , Italy.
出版信息
Leuk Lymphoma. 2016;57(1):116-9. doi: 10.3109/10428194.2015.1046864. Epub 2015 May 25.
In the last decades, evaluation of clinically relevant thrombotic complications in patients with acute leukemia (AL) has been poorly investigated. The authors performed a multi-center study to evaluate the management of symptomatic venous thromboembolism (VTE) in adult patients with AL. The intention was to find as clinically relevant the following: symptomatic Venous Thrombosis (VT) occurred in typical (lower limbs) and atypical (cerebral, upper limbs, abdominal, etc) sites with or without pulmonary embolism (PE). Over a population of 1461 patients with AL, 22 cases of symptomatic VTE were recorded in hospitalized patients with a mean age of 54.6 years. The absolute incidence of VTE was 1.5%. VTE occurred during chemotherapy in 17/22 (77.2%) cases, mainly (14/17, 82.3%) during the induction phase. Treatment of acute VTE was based on Low Molecular Weight Heparin (LMWH) at full dosage for the first month from diagnosis and reduced dosage (75%) for the following months.
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