Sanfilippo Kristen M, Wang Tzu-Fei
Department of Medicine, Washington University School of Medicine, Saint Louis, MO, United States.
John Cochran Saint Louis Veterans Administration Medical Center, Saint Louis, MO, United States.
Bleeding Thromb Vasc Biol. 2024;3(Suppl 1). doi: 10.4081/btvb.2024.119. Epub 2024 May 16.
Mortality and venous thromboembolism (VTE) are major risks for patients with hematological malignancies. However, they are commonly underrepresented in major clinical trials of VTE. Treatment decisions are further complicated by the unique characteristics they frequently exhibit, such as thrombocytopenia. In addition to discussing treatment challenges, knowledge gaps, and future directions, our goal in this narrative review is to provide an overview of the epidemiology and risk factors of mortality in patients with hematological malignancies and VTE.
死亡率和静脉血栓栓塞(VTE)是血液系统恶性肿瘤患者面临的主要风险。然而,在VTE的主要临床试验中,这些患者通常代表性不足。由于他们经常表现出的独特特征,如血小板减少症,治疗决策变得更加复杂。除了讨论治疗挑战、知识空白和未来方向外,我们在这篇叙述性综述中的目标是概述血液系统恶性肿瘤患者合并VTE时的死亡率流行病学和危险因素。