Leon-Cabrera Sonia, Arana-Lechuga Yoaly, Esqueda-León Enrique, Terán-Pérez Guadalupe, Gonzalez-Chavez Antonio, Escobedo Galileo, Velázquez Moctezuma Javier
Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Iztacala, 54090 Tlalnepantla, MEX, Mexico.
Departamento de Biología de la Reproducción y Clínica de Trastornos de Sueño, Universidad Autónoma Metropolitana-Iztapalapa, 09340 México, DF, Mexico.
Mediators Inflamm. 2015;2015:493409. doi: 10.1155/2015/493409. Epub 2015 Apr 6.
Obstructive sleep apnea (OSA) has been related to elevation of inflammatory cytokines and development of insulin resistance in morbidly obese (MO) subjects. However, it is still unclear whether the systemic concentration of anti-inflammatory mediators is also affected in MO subjects directly related to the severity of OSA and level of insulin resistance. Normal weight and MO subjects were subjected to overnight polysomnography in order to establish the severity of OSA, according to the apnea-hypopnea index (AHI). Blood samples were obtained for estimation of total cholesterol and triglycerides, insulin, glucose, insulin resistance, tumor necrosis factor alpha (TNF-α), interleukin 12 (IL12), and interleukin 10 (IL-10). Serum levels of IL-10 were significantly lower in MO subjects with OSA than in MO and control individuals without OSA. Besides being inversely associated with serum TNF-α and IL-12, decreased IL-10 levels were significantly related to increased AHI, hyperinsulinemia, and insulin resistance. Serum IL-10 is significantly reduced in morbidly obese subjects with severe OSA while also showing a clear relationship with a state of hyperinsulinemia and insulin resistance probably regardless of obesity in the present sample. It may be of potential clinical interest to identify the stimulatory mechanisms of IL-10 in obese individuals with OSA.
阻塞性睡眠呼吸暂停（OSA）与病态肥胖（MO）患者体内炎性细胞因子水平升高及胰岛素抵抗的发生有关。然而，与OSA严重程度和胰岛素抵抗水平直接相关的MO患者体内抗炎介质的全身浓度是否也受到影响仍不清楚。根据呼吸暂停低通气指数（AHI），对正常体重和MO受试者进行整夜多导睡眠监测，以确定OSA的严重程度。采集血样以测定总胆固醇、甘油三酯、胰岛素、葡萄糖、胰岛素抵抗、肿瘤坏死因子α（TNF-α）、白细胞介素12（IL12）和白细胞介素10（IL-10）。伴有OSA的MO患者血清IL-10水平显著低于无OSA的MO患者和对照个体。除了与血清TNF-α和IL-12呈负相关外，IL-10水平降低还与AHI升高、高胰岛素血症和胰岛素抵抗显著相关。在患有严重OSA的病态肥胖受试者中，血清IL-10显著降低，同时在本样本中，无论是否肥胖，血清IL-10也与高胰岛素血症和胰岛素抵抗状态呈现明显关联。识别OSA肥胖个体中IL-10的刺激机制可能具有潜在的临床意义。
