Mansouri Mehran, Imenshahidi Mohsen, Rameshrad Maryam, Hosseinzadeh Hossein
Student Research Committee, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398(5):4979-5009. doi: 10.1007/s00210-024-03642-2. Epub 2024 Dec 28.
Metabolic syndrome is a cluster of some conditions such as high blood sugar, high blood triglycerides, low HDL cholesterol, abdominal obesity, and high blood pressure. Introducing a drug or a food that manages the majority of these medical conditions is invaluable. Tinospora cordifolia, known as guduchi and giloy, is a medicinal herb in ayurvedic medicine that is used in the treatment of various diseased conditions and also as a food for the maintenance of health. Here, we reviewed the current evidence supporting the role of giloy in the development and treatment of metabolic syndrome components. Appropriate articles that have been published until May 2024 were carefully extracted from PubMed, Scopus, and WOS databases to write a narrative review systematically. Gathered data showed the beneficial effects of giloy on metabolic syndrome components: hyperlipidemia, obesity, atherosclerosis, hypertension, and especially diabetes mellitus. As diabetes and insulin resistance seem to be a central feature of metabolic syndrome and in turn, can cause dyslipidemia, obesity, and, atherosclerosis, these beneficial effects are predictable with the anti-diabetogenic property of giloy. In this review, the main mechanisms of action of giloy in metabolic syndrome components are discussed. Based on the results, although giloy has been less investigated, considerable studies provide evidence of its beneficial effects on different components of metabolic syndrome. Relevant clinical trials are necessary to validate the mentioned effects, safety, and optimum dose of this herbal medicine and its components in managing different components of metabolic syndrome and transition from bench to bedside.
代谢综合征是一系列病症的集合，如高血糖、高甘油三酯血症、低高密度脂蛋白胆固醇、腹部肥胖和高血压。引入一种能控制这些大多数病症的药物或食物是非常有价值的。匙羹藤，又称古杜奇和吉洛伊，是阿育吠陀医学中的一种草药，用于治疗各种疾病，也作为维持健康的食物。在此，我们综述了目前支持吉洛伊在代谢综合征各组分发生和治疗中作用的证据。从PubMed、Scopus和WOS数据库中仔细提取了截至2024年5月已发表的相关文章，以系统地撰写一篇叙述性综述。收集的数据显示了吉洛伊对代谢综合征各组分的有益作用：高脂血症、肥胖、动脉粥样硬化、高血压，尤其是糖尿病。由于糖尿病和胰岛素抵抗似乎是代谢综合征的核心特征，进而可导致血脂异常、肥胖和动脉粥样硬化，这些有益作用可通过吉洛伊的抗糖尿病特性预测。在本综述中，讨论了吉洛伊在代谢综合征各组分中的主要作用机制。基于这些结果，尽管对吉洛伊的研究较少，但大量研究提供了其对代谢综合征不同组分有益作用的证据。需要进行相关临床试验，以验证这种草药及其成分在管理代谢综合征不同组分以及从实验室到临床应用中的上述效果、安全性和最佳剂量。
