Schierano Gianmario, Mussano Federico, Faga Maria Giulia, Menicucci Giulio, Manzella Carlo, Sabione Cristian, Genova Tullio, von Degerfeld Mitzy Mauthe, Peirone Bruno, Cassenti Adele, Cassoni Paola, Carossa Stefano
Department of Surgical Sciences, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy.
CNR-IMAMOTER, Strada delle Cacce 73, 10135 Turin, Italy ; CNR-IMAMOTER (Headquarters), Via Canal Bianco 28, 44124 Ferrara, Italy.
Biomed Res Int. 2015;2015:157360. doi: 10.1155/2015/157360. Epub 2015 Apr 6.
Ceramic materials are widely used for biomedical applications because of their remarkable biological and mechanical properties. Composites made of alumina and zirconia are particularly interesting owing to their higher toughness with respect to the monolithic materials. On this basis, the present study is focused on the in vivo behavior of alumina toughened zirconia (ATZ) dental implants treated with a hydrothermal process. A minipig model was implemented to assess the bone healing through histology and mRNA expression at different time points (8, 14, 28, and 56 days). The novel ATZ implant was compared to a titanium clinical standard. The implants were analyzed in terms of microstructure and surface roughness before in vivo tests. The most interesting result deals with a statistically significant higher digital histology index for ATZ implants with respect to titanium standard at 56 days, which is an unprecedented finding, to the authors' knowledge. Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.
陶瓷材料因其卓越的生物学和力学性能而被广泛应用于生物医学领域。由氧化铝和氧化锆制成的复合材料尤其引人关注，因为相较于单一材料，它们具有更高的韧性。在此基础上，本研究聚焦于经水热工艺处理的氧化铝增韧氧化锆（ATZ）牙科植入物的体内行为。采用小型猪模型，通过组织学和不同时间点（8天、14天、28天和56天）的mRNA表达来评估骨愈合情况。将新型ATZ植入物与钛临床标准进行比较。在体内测试前，对植入物的微观结构和表面粗糙度进行了分析。最有趣的结果是，在56天时，ATZ植入物的数字组织学指数相对于钛标准具有统计学上的显著更高值，据作者所知，这是一个前所未有的发现。即使在提议用于人类临床之前还需要进一步研究，但经测试的材料在可能的陶瓷牙科植入物中被证明是一个有前途的候选者。
