Devito A
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Clin Ter. 2015;166(2):e114-7. doi: 10.7417/CT.2015.1832.
Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 and its ligand chemokines, as monokine induced by interferon (IFN)-γ (MIG), interferon-γ inducible protein (IP-10) and IFN-inducible T cell-α chemoattractant (I-TAC), are strongly overexpressed both in the intestinal mucosa of mice with experimental colitis, and in patients with Crohn's disease (CD) in lymphocytes, in macrophages and in epithelial cells. IFN-γ induces CXCR3 and its chemokines expression in epithelial intestinal cells; these chemokines are important for the recruitment of granulocytes and mononuclear cells, thus for the maintenance of inflammation in CD. Serum IP-10 levels might reflect CD disease activity, and it may be a marker for the responsiveness of patients to treatments. However other studies are needed to document the use of IP-10 in clinical setting. Attempts are currently underway to inhibit CXCR3 or its chemokines in CD as a possible therapy of CD.
许多研究表明，趋化因子（C-X-C基序）受体（CXCR）3及其配体趋化因子，如γ干扰素（IFN）诱导的单核因子（MIG）、γ干扰素诱导蛋白（IP-10）和IFN诱导的T细胞α趋化因子（I-TAC），在患有实验性结肠炎的小鼠肠道黏膜中，以及在克罗恩病（CD）患者的淋巴细胞、巨噬细胞和上皮细胞中均强烈过表达。IFN-γ可诱导肠道上皮细胞中CXCR3及其趋化因子的表达；这些趋化因子对于粒细胞和单核细胞的募集很重要，因此对于CD中的炎症维持也很重要。血清IP-10水平可能反映CD疾病活动情况，并且它可能是患者对治疗反应性的一个标志物。然而，需要其他研究来证明IP-10在临床环境中的应用。目前正在尝试抑制CD中的CXCR3或其趋化因子，作为CD的一种可能治疗方法。
