Ragusa F
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Clin Ter. 2015;166(2):e126-31. doi: 10.7417/CT.2015.1835.
Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 (a chemokine receptor in the CXC family) and its ligand chemokines, monokine induced by interferon (IFN)-γ(MIG), IFN-γ-inducible protein 10 (IP-10) and IFN-inducible T-cell α chemoattractant (I-TAC), are strongly overexpressed in the intestinal mucosa of mice with experimental colitis, and in patients with ulcerative colitis (UC) both in lymphocytes, in macrophages and in epithelial cells. IFN-γ induces CXCR3 and its chemokines expression in epithelial colonic cells; MIG, IP-10 and I-TAC are important for the recruitment of granulocytes and mononuclear cells and thus for the maintenance of inflammation in UC. Serum IP-10 levels reflected UC disease activity, and it may be a marker for the responsiveness of patients to treatments. Recently, a phase II study suggested that an anti-IP-10 antibody, BMS-936557, is a potentially effective therapy for moderately-to-severely active UC.
许多研究表明，趋化因子（C-X-C基序）受体（CXCR）3（CXC家族中的一种趋化因子受体）及其配体趋化因子，即干扰素（IFN）-γ诱导的单核因子（MIG）、IFN-γ诱导蛋白10（IP-10）和IFN诱导的T细胞α趋化因子（I-TAC），在实验性结肠炎小鼠的肠黏膜中以及溃疡性结肠炎（UC）患者的淋巴细胞、巨噬细胞和上皮细胞中均强烈过表达。IFN-γ可诱导结肠上皮细胞中CXCR3及其趋化因子的表达；MIG、IP-10和I-TAC对于粒细胞和单核细胞的募集很重要，因此对于UC炎症的维持也很重要。血清IP-10水平反映了UC的疾病活动，它可能是患者对治疗反应性的一个标志物。最近，一项II期研究表明，抗IP-10抗体BMS-936557是中重度活动性UC的一种潜在有效疗法。
