嗅神经母细胞瘤转移至鼻窦的可能性：临床报告及文献综述
Possible esthesioneuroblastoma metastasis to paranasal sinuses: Clinical report and literature review.
作者信息
Buohliqa Lamia, Upadhyay Smita, Nicolai Piero, Cavalieri Robert, Dolci Ricardo L L, Prevedello Daniel, Carrau Ricardo L
机构信息
Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at The Ohio State University, Columbus, Ohio.
Department of Otolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy.
出版信息
Head Neck. 2016 Feb;38(2):E32-6. doi: 10.1002/hed.24095. Epub 2015 Jul 14.
BACKGROUND
Local recurrence, and regional and distant metastases, respectively, develop in 30% and 15% of patients with esthesioneuroblastoma (ENB).
METHODS
This case report includes 3 patients with unusual recurrences of ENB in the sinonasal tract.
RESULTS
Patient 1 developed ENB in the bilateral maxillary sinuses after unilateral endoscopic resection of a left ENB followed by postoperative proton radiotherapy. Patient 2 developed ENB at the left optic-carotid recess 7 years after a craniofacial resection and postoperative radiotherapy. Patient 3 developed ENB over the left zygomatic process of the maxilla 4 years after a cranioendoscopic resection and postoperative radiation therapy for ENB of the ethmoid sinuses with intracranial extension. The possibility of venous tumor emboli must be considered as a likely etiology. However, alternative explanations include the development of a second primary or potential transformation because of tumor signaling.
CONCLUSION
We present 3 cases that may represent metastasis of ENB within the sinonasal tract.
背景
嗅神经母细胞瘤（ENB）患者中，局部复发、区域转移和远处转移的发生率分别为30%和15%。
方法
本病例报告包括3例鼻窦内ENB异常复发的患者。
结果
患者1在左侧ENB单侧内镜切除并术后质子放疗后，双侧上颌窦发生ENB。患者2在颅面切除和术后放疗7年后，左侧视交叉 - 颈动脉隐窝发生ENB。患者3在筛窦ENB伴颅内扩展的颅内镜切除和术后放疗4年后，上颌骨左侧颧突发生ENB。必须考虑静脉肿瘤栓子作为可能病因的可能性。然而，其他解释包括第二原发性肿瘤的发生或肿瘤信号导致的潜在转化。
结论
我们报告了3例可能代表ENB在鼻窦内转移的病例。
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