De Fabiani E, Crestani M, Malavasi B, Del Puppo M, Farina F, Armocida C, Bellentani S, Quack G, Bosisio E
Institute of Pharmacological Sciences, University of Milan, Italy.
Pharmacol Res. 1989 Sep-Oct;21(5):567-76. doi: 10.1016/1043-6618(89)90198-9.
Hamsters were given etofibrate at a dose of 300 mg/kg body wt, by gavage for 5 days, while being fed a chow diet. After treatment, serum cholesterol levels were 27% lower compared to those of the control animals. A similar trend was observed for triglyceride levels. Hepatic lipid levels were unchanged by the treatment. HMG-CoA reductase and acylCoA cholesterol acyltransferase were decreased while cholesterol 7 alpha-hydroxylase was not significantly modified by etofibrate. A choleretic effect and an increase of cholesterol excretion into hepatic bile was observed in treated animals. Nevertheless, composition and cholesterol saturation index of gallbladder bile were similar in control and treated animals. With respect to controls, hepatic bile of treated hamsters contained a lesser amount of cholic and deoxycholic acid and a greater amount of ursodeoxycholic acid.
给仓鼠经口灌胃给予剂量为300mg/kg体重的益多酯，持续5天，同时给予普通饲料。治疗后，与对照动物相比，血清胆固醇水平降低了27%。甘油三酯水平也观察到类似趋势。治疗对肝脏脂质水平无影响。益多酯使HMG-CoA还原酶和酰基辅酶A胆固醇酰基转移酶降低，而胆固醇7α-羟化酶未受到显著影响。在接受治疗的动物中观察到利胆作用以及肝脏胆汁中胆固醇排泄增加。然而，对照动物和治疗动物的胆囊胆汁成分和胆固醇饱和指数相似。与对照组相比，接受治疗的仓鼠肝脏胆汁中胆酸和脱氧胆酸含量较少，熊去氧胆酸含量较多。
