Bellentani S, Bosisio E, Pecorari M, De Fabiani E, Cordoma P, Crestani M, Manenti F
Pharmacol Res Commun. 1987 May;19(5):327-39. doi: 10.1016/0031-6989(87)90070-1.
This study reports the effect of short-term tauroursodeoxycholic acid (TUDCA) and of TUDCA with addition of taurine on the lipid composition of gallbladder bile, on cholesterol and bile acid synthesis and intestinal excretion, in the female hamsters. After either one or two weeks, the percentage of ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in bile of treated hamsters significantly increased. Both treatments (TUDCA alone or TUDCA + taurine) decreased the percentage of cholic acid without affecting 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase or cholesterol 7 alpha-hydroxylase activities. Sterol and bile acid content of the feces collected during the period of the study did not show any difference. Bile acid glycine to taurine conjugation ratio (G/T ratio) in TUDCA treated animals was significantly higher in respect to controls after only one week of treatment. On the contrary, bile acid G/T ratio significantly decreased in the group of animals supplemented with taurine, but only after two weeks of treatment.
本研究报告了短期牛磺熊去氧胆酸（TUDCA）以及添加牛磺酸的TUDCA对雌性仓鼠胆囊胆汁脂质成分、胆固醇和胆汁酸合成及肠道排泄的影响。在治疗一周或两周后，接受治疗的仓鼠胆汁中熊去氧胆酸（UDCA）和鹅去氧胆酸（CDCA）的百分比显著增加。两种治疗方法（单独使用TUDCA或TUDCA+牛磺酸）均降低了胆酸的百分比，而不影响3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶或胆固醇7α-羟化酶的活性。研究期间收集的粪便中固醇和胆汁酸含量没有显示出任何差异。仅在治疗一周后，TUDCA治疗的动物中胆汁酸甘氨酸与牛磺酸的结合率（G/T比）相对于对照组显著更高。相反，补充牛磺酸的动物组中胆汁酸G/T比显著降低，但仅在治疗两周后出现。
