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Transfer of Alopecia Areata to C3H/HeJ Mice Using Cultured Lymph Node-Derived Cells.

作者信息

Wang Eddy H C, Khosravi-Maharlooei Mohsen, Jalili Reza Baradar, Yu Richard, Ghahary Aziz, Shapiro Jerry, McElwee Kevin J

机构信息

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

J Invest Dermatol. 2015 Oct;135(10):2530-2532. doi: 10.1038/jid.2015.176. Epub 2015 May 6.

DOI:10.1038/jid.2015.176
PMID:25946709
Abstract
摘要

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本文引用的文献

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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.斑秃由细胞毒性 T 淋巴细胞驱动，并可被 JAK 抑制逆转。
Nat Med. 2014 Sep;20(9):1043-9. doi: 10.1038/nm.3645. Epub 2014 Aug 17.
2
Autoimmune disease induction in a healthy human organ: a humanized mouse model of alopecia areata.在健康人体器官中诱导自身免疫性疾病：斑秃的人源化小鼠模型
J Invest Dermatol. 2013 Mar;133(3):844-847. doi: 10.1038/jid.2012.365. Epub 2012 Oct 25.
3
Etiopathogenesis of alopecia areata: Why do our patients get it?斑秃的病因学发病机制：为什么我们的患者会得斑秃？
Int J Mol Sci. 2024 May 22;25(11):5652. doi: 10.3390/ijms25115652.
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CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata.CXCL12 中和抗体促进雄激素性脱发和斑秃的毛发生长。
Int J Mol Sci. 2024 Jan 30;25(3):1705. doi: 10.3390/ijms25031705.
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Screening for latent infectious disease in patients with alopecia areata before initiating JAK inhibitors therapy: a single-center real-world retrospective study.斑秃患者在开始使用JAK抑制剂治疗前进行潜伏性传染病筛查：一项单中心真实世界回顾性研究。
Front Med (Lausanne). 2023 Oct 18;10:1287139. doi: 10.3389/fmed.2023.1287139. eCollection 2023.
6
A virtual memory CD8 T cell-originated subset causes alopecia areata through innate-like cytotoxicity.一种源于虚拟记忆 CD8 T 细胞的亚群通过类似先天的细胞毒性导致斑秃。
Nat Immunol. 2023 Aug;24(8):1308-1317. doi: 10.1038/s41590-023-01547-5. Epub 2023 Jun 26.
7
An overview of JAK/STAT pathways and JAK inhibition in alopecia areata.斑秃中 JAK/STAT 通路和 JAK 抑制的概述。
Front Immunol. 2022 Aug 30;13:955035. doi: 10.3389/fimmu.2022.955035. eCollection 2022.
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Selective Expansion of Tregs Using the IL-2 Cytokine Antibody Complex Does Not Reverse Established Alopecia Areata in C3H/HeJ Mice.采用 IL-2 细胞因子抗体复合物选择性扩增 Tregs 并不能逆转 C3H/HeJ 小鼠的已确立的斑秃。
Front Immunol. 2022 Jun 15;13:874778. doi: 10.3389/fimmu.2022.874778. eCollection 2022.
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The current state of knowledge of the immune ecosystem in alopecia areata.斑秃免疫生态系统的当前知识状态。
Autoimmun Rev. 2022 May;21(5):103061. doi: 10.1016/j.autrev.2022.103061. Epub 2022 Feb 10.
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NLRP3 inflammasome activation contributes to development of alopecia areata in C3H/HeJ mice.NLRP3 炎性小体激活导致 C3H/HeJ 小鼠发生斑秃。
Exp Dermatol. 2022 Feb;31(2):133-142. doi: 10.1111/exd.14432. Epub 2021 Jul 26.
Dermatol Ther. 2011 May-Jun;24(3):337-47. doi: 10.1111/j.1529-8019.2011.01416.x.
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The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results.斑秃的C3H/HeJ小鼠和DEBR大鼠模型：临床前药物筛选方法及结果综述
Exp Dermatol. 2008 Oct;17(10):793-805. doi: 10.1111/j.1600-0625.2008.00773.x.
5
What can we learn from animal models of Alopecia areata?我们能从斑秃动物模型中学到什么？
Dermatology. 2005;211(1):47-53. doi: 10.1159/000085580.
6
Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25(-) cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model.在C3H/HeJ小鼠模型中，转移CD8(+)细胞会导致局部脱发，而CD4(+)/CD25(-)细胞会促进系统性斑秃，CD4(+)/CD25(+)细胞则会阻止疾病发作。
J Invest Dermatol. 2005 May;124(5):947-57. doi: 10.1111/j.0022-202X.2005.23692.x.
7
Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts.使用全层皮肤移植在C3H/HeJ小鼠中实验性诱导斑秃样脱发
J Invest Dermatol. 1998 Nov;111(5):797-803. doi: 10.1046/j.1523-1747.1998.00380.x.
8
Alopecia areata in aging C3H/HeJ mice.衰老C3H/HeJ小鼠中的斑秃
J Invest Dermatol. 1994 Jun;102(6):847-56. doi: 10.1111/1523-1747.ep12382416.
9
The DEBR rat model for alopecia areata.斑秃的DEBR大鼠模型。
J Invest Dermatol. 1991 May;96(5):97S. doi: 10.1111/1523-1747.ep12472251.