通过脱三氟乙酰基曼尼希反应实现季碳α-氟-β-酮胺的不对称合成。
Asymmetric synthesis of quaternary α-fluoro-β-keto-amines via detrifluoroacetylative Mannich reactions.
作者信息
Xie Chen, Dai Yanling, Mei Haibo, Han Jianlin, Soloshonok Vadim A, Pan Yi
机构信息
School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093, China.
出版信息
Chem Commun (Camb). 2015 Jun 4;51(44):9149-52. doi: 10.1039/c5cc02256h.
PMID:25947253
Abstract
Efficient asymmetric detrifluoroacetylative Mannich addition reactions between 2-fluoro-1,3-di-ketones/hydrates and chiral N-sulfinyl-imines via C-C bond cleavage were reported, which afforded C-F quaternary α-fluoro-β-keto-amines with excellent yields and high diastereoselectivity.
摘要
报道了通过碳-碳键断裂实现的2-氟-1,3-二酮/水合物与手性N-亚磺酰亚胺之间高效的不对称脱三氟乙酰基曼尼希加成反应，该反应以优异的产率和高非对映选择性得到了含碳-氟季碳的α-氟-β-酮胺。
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