芳基氟乙腈的催化不对称烯丙基烷基化反应。
Catalytic Asymmetric Allylic Alkylation with Arylfluoroacetonitriles.
机构信息
Department of Chemistry, Georgetown University, 37th and O Streets, Washington, DC 20057, United States.
出版信息
J Org Chem. 2022 Sep 2;87(17):11880-11887. doi: 10.1021/acs.joc.2c01414. Epub 2022 Aug 17.
Abstract
A palladium(phosphinoxazoline) catalyzed method for asymmetric allylic alkylation of α-aryl-α-fluoroacetonitriles is introduced. This reaction achieves C-C bond formation and incorporation of two adjacent chirality centers with moderate to good yields, high enantioselectivities, and up to 15:1 .
摘要
介绍了一种钯（膦氮杂环戊二烯）催化的α-芳基-α-氟乙腈的不对称烯丙基烷基化方法。该反应以中等至良好的收率、高对映选择性和高达 15:1 的比例实现了 C-C 键的形成和两个相邻手性中心的引入。
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