Chen M Z, Chen F R, Mao J M, Guo J X, Xie D Y, Xu J R
Proc Chin Acad Med Sci Peking Union Med Coll. 1989;4(3):131-4.
This study was to assess the potential application of excimer lasers in the ablation of myocardium in vitro for the treatment of constant ventricular tachycardia or hypertrophic cardiomyopathy. A fresh human heart and EMG model 103 XeCl pulse excimer laser machine were used. The pulse repetition rate varied from 1 to 7 Hz. Irradiation directly on the left endocardial and epicardial walls lasted for 10 seconds and was repeated 3 times, creating 3 craters. The histological changes were examined by light microscope. Results showed very close relations between the depth or volume of vaporized craters and the pulse repetition rate on the endocardial (r = 0.9674, P less than 0.001 and r = 0.8962, P less than 0.01, respectively) and epicardial walls (r = 0.9602, P less than 0.001 and r = 0.9612, P less than 0.001, respectively). A sharp, clear border without debris or coagulating necrosis was seen under the microscope. We concluded that the pulse excimer laser, differing from Ar+ or Nd:YAG lasers, might be a powerful tool for manipulating the human ventricular wall, but more work needs to be done before it can be widely applied in the treatment of cardiovascular disease.
本研究旨在评估准分子激光在体外消融心肌以治疗持续性室性心动过速或肥厚型心肌病方面的潜在应用。使用了一个新鲜的人心脏和EMG模型103 XeCl脉冲准分子激光机。脉冲重复频率在1至7赫兹之间变化。直接照射左心内膜和心外膜壁持续10秒，重复3次，形成3个弹坑。通过光学显微镜检查组织学变化。结果显示，在心内膜（分别为r = 0.9674，P < 0.001和r = 0.8962，P < 0.01）和心外膜壁（分别为r = 0.9602，P < 0.001和r = 0.9612，P < 0.001）上，汽化弹坑的深度或体积与脉冲重复频率之间存在非常密切的关系。在显微镜下可见清晰锐利的边界，无碎片或凝固性坏死。我们得出结论，与氩离子或钕：钇铝石榴石激光不同，脉冲准分子激光可能是一种用于操作人心室壁的有力工具，但在其能够广泛应用于心血管疾病治疗之前，还需要做更多的工作。
