主题迷你综述系列介绍：新型生物活性鞘脂类
Introduction to Thematic Minireview Series: Novel Bioactive Sphingolipids.
作者信息
Merrill Alfred H, Carman George M
机构信息
Schools of Biology and Chemistry & Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; Schools of Biology and Chemistry & Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332; Schools of Biology and Chemistry & Biochemistry, and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332.
Department of Food Science, Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, New Jersey 08901.
出版信息
J Biol Chem. 2015 Jun 19;290(25):15362-15364. doi: 10.1074/jbc.R115.663708. Epub 2015 May 6.
Sphingosine was named by J. L. W. Thudichum for its enigmatic properties. This descriptor has applied to sphingolipids for over a century because new enigmas continue to surface. This JBC minireview series presents articles about three novel subspecies of sphingolipids, α-galactosylceramides, 4,5-dihydroceramides, and 1-deoxysphingolipids, that have important activities but, until recently, remained undetected (or at least understudied) in the shadow of very closely related compounds. They also serve as a reminder that important metabolites still lie "off the radar screen" in reports of global and comprehensive metabolomic profiling.
鞘氨醇因其神秘特性由J. L. W. 蒂迪雄命名。由于新的谜团不断涌现，这个描述词已应用于鞘脂类一个多世纪了。这个《生物化学杂志》小型综述系列呈现了关于三种新型鞘脂类亚种的文章，即α-半乳糖基神经酰胺、4,5-二氢神经酰胺和1-脱氧鞘脂类，它们具有重要活性，但直到最近，在与其密切相关的化合物的阴影下仍未被发现（或至少未得到充分研究）。它们也提醒人们，在全球全面代谢组学分析报告中，重要的代谢物仍处于“未被关注”状态。
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