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犬体内由曲霉属真菌引起的霉菌性动脉瘤。

Mycotic aneurysm caused by Graphium species in a dog.

作者信息

Murata Yousuke, Chambers James Kenn, Uchida Kazuyuki, Nakashima Ko, Hanafusa Yasuko, Ikezawa Mitsutaka, Sugita Takashi, Nakayama Hiroyuki

机构信息

Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

出版信息

J Vet Med Sci. 2015 Oct;77(10):1285-8. doi: 10.1292/jvms.15-0105. Epub 2015 May 3.

Abstract

A 10-year-old castrated male mixed-breed dog exhibited vomiting, lethargy and anorexia. An abdominal ultrasound examination revealed a focal dilation of the abdominal aorta. The dog died 2 days after examination, and necropsy revealed a ruptured aneurysm at the abdominal aorta between the kidneys. Histological examination revealed severe granulomatous and necrotizing pan-arteritis with fungal organisms. Graphium species was identified through DNA sequence analysis of the PCR product from formalin-fixed paraffin-embedded samples. To our knowledge, this is the first report of aortic aneurysm caused by Graphium species in a dog. Sequence was submitted to the DNA Data Bank of Japan with the accession number LC007972.

摘要

一只10岁去势雄性混血犬出现呕吐、嗜睡和厌食症状。腹部超声检查显示腹主动脉局部扩张。该犬在检查后2天死亡,尸检发现双肾之间的腹主动脉有动脉瘤破裂。组织学检查显示严重的肉芽肿性和坏死性全动脉炎,并伴有真菌。通过对福尔马林固定石蜡包埋样本的PCR产物进行DNA序列分析,鉴定出为枝顶孢属真菌。据我们所知,这是犬类中由枝顶孢属真菌引起主动脉瘤的首例报告。序列已提交至日本DNA数据库,登录号为LC007972。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7c4/4638297/58a529c438fd/jvms-77-1285-g001.jpg

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